CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022
Cash flows from operating activities:
Net loss	$ (188,140)	$ (249,461)
Adjustments to reconcile net loss to net cash used in operating activities:
Non-cash royalty revenue related to the sales of future royalties	(32,693)	(33,825)
Non-cash interest expense on liabilities related to the sales of future royalties	12,557	14,757
Change in fair value of development derivative liability	0	(33,427)
Non-cash research and development expense	0	4,951
Stock-based compensation	17,985	32,064
Depreciation and amortization	4,468	7,171
Deferred income tax expense	(1,839)	0
Impairment of right-of-use assets and property, plant and equipment	26,455	57,321
Impairment of goodwill	76,501	0
Amortization of premiums (discounts), net and other non-cash transactions	(8,150)	700
Changes in operating assets and liabilities:
Accounts receivable	4,646	12,486
Inventory	(1,487)	(1,168)
Operating leases, net	(3,717)	1,486
Other assets	7,902	7,627
Accounts payable	(9,997)	2,833
Accrued expenses	(7,929)	13,068
Net cash used in operating activities	(103,438)	(163,417)
Cash flows from investing activities:
Purchases of investments	(249,724)	(247,014)
Maturities of investments	316,088	466,423
Purchases of property, plant and equipment	(595)	(4,983)
Net cash provided by investing activities	65,769	214,426
Cash flows from financing activities:
Proceeds from shares issued under equity compensation plans	18	655
Cash receipts from development derivative liability	0	750
Net cash provided by financing activities	18	1,405
Effect of foreign exchange rates on cash and cash equivalents	152	(87)
Net increase (decrease) in cash and cash equivalents	(37,499)	52,327
Cash and cash equivalents at beginning of period	88,227	25,218
Cash and cash equivalents at end of period	50,728	77,545
Supplemental disclosures of cash flow information:
Cash paid for income taxes	$ 2,656	$ 85