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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
6 Months Ended
Jun. 30, 2023
Jun. 30, 2022
Cash flows from operating activities:    
Net loss $ (188,140) $ (249,461)
Adjustments to reconcile net loss to net cash used in operating activities:    
Non-cash royalty revenue related to the sales of future royalties (32,693) (33,825)
Non-cash interest expense on liabilities related to the sales of future royalties 12,557 14,757
Change in fair value of development derivative liability 0 (33,427)
Non-cash research and development expense 0 4,951
Stock-based compensation 17,985 32,064
Depreciation and amortization 4,468 7,171
Deferred income tax expense (1,839) 0
Impairment of right-of-use assets and property, plant and equipment 26,455 57,321
Impairment of goodwill 76,501 0
Amortization of premiums (discounts), net and other non-cash transactions (8,150) 700
Changes in operating assets and liabilities:    
Accounts receivable 4,646 12,486
Inventory (1,487) (1,168)
Operating leases, net (3,717) 1,486
Other assets 7,902 7,627
Accounts payable (9,997) 2,833
Accrued expenses (7,929) 13,068
Net cash used in operating activities (103,438) (163,417)
Cash flows from investing activities:    
Purchases of investments (249,724) (247,014)
Maturities of investments 316,088 466,423
Purchases of property, plant and equipment (595) (4,983)
Net cash provided by investing activities 65,769 214,426
Cash flows from financing activities:    
Proceeds from shares issued under equity compensation plans 18 655
Cash receipts from development derivative liability 0 750
Net cash provided by financing activities 18 1,405
Effect of foreign exchange rates on cash and cash equivalents 152 (87)
Net increase (decrease) in cash and cash equivalents (37,499) 52,327
Cash and cash equivalents at beginning of period 88,227 25,218
Cash and cash equivalents at end of period 50,728 77,545
Supplemental disclosures of cash flow information:    
Cash paid for income taxes $ 2,656 $ 85