CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
Revenue:
Total revenue	$ 20,499	$ 21,585	$ 42,093	$ 46,407
Operating costs and expenses:
Cost of goods sold	6,994	5,115	14,054	10,430
Research and development	29,681	42,740	60,150	149,993
General and administrative	17,869	20,521	38,950	47,860
Restructuring, impairment and costs of terminated program	16,554	106,045	37,747	107,520
Impairment of goodwill	0	0	76,501	0
Total operating costs and expenses	71,098	174,421	227,402	315,803
Loss from operations	(50,599)	(152,836)	(185,309)	(269,396)
Non-operating income (expense):
Change in fair value of development derivative liability	0	0	0	33,427
Non-cash interest expense on liabilities related to the sales of future royalties	(6,152)	(7,228)	(12,557)	(14,757)
Interest income and other income (expense), net	5,582	1,096	9,616	1,491
Total non-operating income (expense), net	(570)	(6,132)	(2,941)	20,161
Loss before provision for income taxes	(51,169)	(158,968)	(188,250)	(249,235)
Provision (benefit) for income taxes	(47)	100	(110)	226
Net loss	$ (51,122)	$ (159,068)	$ (188,140)	$ (249,461)
Basic net loss per share (in dollars per share)	$ (0.27)	$ (0.85)	$ (0.99)	$ (1.34)
Diluted net loss per share (in dollars per share)	$ (0.27)	$ (0.85)	$ (0.99)	$ (1.34)
Weighted average shares outstanding used in computing basic net loss per share (in shares)	189,656	186,800	189,268	186,323
Weighted average shares outstanding used in computing diluted net loss per share (in shares)	189,656	186,800	189,268	186,323
Product sales
Revenue:
Total revenue	$ 4,658	$ 5,312	$ 9,376	$ 11,000
Non-cash royalty revenue related to the sales of future royalties
Revenue:
Total revenue	15,832	16,264	32,693	33,825
License, collaboration and other revenue
Revenue:
Total revenue	$ 9	$ 9	$ 24	$ 1,582