CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	12 Months Ended			130 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2022
Cash flows from operating activities:
Net loss	$ (368,198)	$ (523,837)	$ (444,440)
Adjustments to reconcile net loss to net cash used in operating activities:
Non-cash royalty revenue related to the sales of future royalties	(69,794)	(77,746)	(48,563)	$ (403,245)
Non-cash interest expense on liabilities related to sales of future royalties	28,911	47,313	30,267	273,184
Loss on revaluation of liability related to the sale of future royalties	0	24,410	0
Change in fair value of development derivative liability	(33,427)	8,023	0
Non-cash research and development expense	4,951	16,703	0
Stock-based compensation	57,320	94,674	94,261
Depreciation and amortization	13,030	14,146	14,182
Deferred income tax expense	2,708	(102)	(36)
Impairment of right-of-use assets and property, plant and equipment	65,761	0	0
(Gain) loss on sale or disposal of property, plant and equipment, net	(3,326)	0	0
Impairment of advance payments to contract manufacturers and equipment for terminated program	0	0	20,351
Amortization of premiums (discounts), net and other non-cash transactions	(2,435)	6,730	3,943
Changes in operating assets and liabilities:
Accounts receivable	16,511	12,397	1,913
Inventory	(3,401)	(509)	(2,627)
Operating leases, net	(2,680)	2,340	2,743
Other assets	6,906	(2,586)	4,512
Accounts payable	3,103	(11,690)	2,382
Accrued compensation	(6,153)	1,203	4,697
Other accrued expenses	(12,734)	(23,524)	8,644
Deferred revenue	(1,060)	(605)	(5,516)
Net cash used in operating activities	(304,007)	(412,660)	(313,287)
Cash flows from investing activities:
Purchases of investments	(467,914)	(960,689)	(987,533)
Maturities of investments	826,229	1,166,951	1,449,304
Sales of investments	0	11,504	41,700
Purchases of property, plant and equipment	(5,676)	(14,989)	(7,258)
Sales of property, plant and equipment	13,196	0	0
Net cash provided by investing activities	365,835	202,777	496,213
Cash flows from financing activities:
Proceeds from sale of future royalties, net of $3.8 million of transaction costs	0	0	146,250
Repayment of senior notes	0	0	(250,000)
Cash receipts from development derivative liability	750	3,000	0
Proceeds from shares issued under equity compensation plans	758	33,238	23,396
Net cash provided by (used in) financing activities	1,508	36,238	(80,354)
Effect of foreign exchange rates on cash and cash equivalents	(327)	(92)	20
Net increase (decrease) in cash and cash equivalents	63,009	(173,737)	102,592
Cash and cash equivalents at beginning of year	25,218	198,955	96,363
Cash and cash equivalents at end of year	88,227	25,218	198,955	$ 88,227
Supplemental disclosure of cash flow information:
Cash paid for interest	0	0	9,742
Cash paid for income taxes	272	325	539
Operating lease right-of-use assets recognized in exchange for lease liabilities	0	1,057	2,133
Accounts receivable recognized in exchange for long-term liabilities	$ 0	$ 0	$ 4,000