Income Taxes - Additional Information (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Income Taxes Disclosure [Line Items]
Increase in valuation allowance	$ 30,500	$ 115,600
Operating loss carryforwards, subject to expiration	1,300,000
Income tax research credits	987	4,727	$ 3,081
Unrecognized tax benefits, interest recognized	0	0	0
Unrecognized tax benefits, penalties recognized	$ 0	$ 0	$ 0
Unrecognized tax benefits, period may increase or decrease due to tax examination	12 months
Federal
Income Taxes Disclosure [Line Items]
Operating loss carryforwards	$ 2,400,000
Income tax research credits	123,800
State
Income Taxes Disclosure [Line Items]
Operating loss carryforwards	700,000
Income tax research credits	$ 48,800