Income Taxes - Schedule of Significant Components of Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021
Deferred tax assets:
Net operating loss carryforwards	$ 545,508	$ 564,712
Research and other credits	142,198	139,996
Net capital loss carryforwards	38,445	0
Operating lease liabilities	28,254	34,680
Stock-based compensation	22,110	33,408
Capitalized research and development costs	24,134	0
Liability related to the sale of future royalties	13,424	23,757
Other	13,935	17,290
Deferred tax assets before valuation allowance	828,008	813,843
Valuation allowance for deferred tax assets	(816,235)	(785,748)
Total deferred tax assets	11,773	28,095
Deferred tax liabilities:
Operating lease right-of-use assets	(11,335)	(27,204)
Investment in foreign subsidiary	(2,451)	0
Other	(392)	(564)
Total deferred tax liabilities	(14,178)	(27,768)
Total deferred tax liabilities	$ (2,405)
Net deferred tax assets (liabilities)		$ 327