Stockholders' Equity - Additional Information (Details) - USD ($)	Apr. 03, 2018	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Class of Stock [Line Items]
Stock issued during period subject to lock-up and stand-still provisions period	5 years
Aggregate offering price		$ 300,000,000
Losses recorded in AOCI		(366,638,000)	$ (679,508,000)	$ (1,077,295,000)	$ (1,405,391,000)
Common Stock
Class of Stock [Line Items]
Sale of stock to Bristol-Myers Squibb (in shares)	8,284,600
Losses recorded in AOCI		(19,000)	$ (19,000)	$ (18,000)	$ (17,000)
AOCI, Accumulated Gain (Loss), Debt Securities, Available-for-Sale, Parent
Class of Stock [Line Items]
Losses recorded in AOCI		1,800,000
Accumulated Foreign Currency Adjustment Attributable to Parent
Class of Stock [Line Items]
Losses recorded in AOCI		$ 5,100,000