Liabilities Related to the Sales of Future Royalties - Schedule of Liability Related to Potential Future Royalties (Detail) - USD ($) $ in Thousands	12 Months Ended			24 Months Ended	130 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2022	Dec. 31, 2022
Liability Related To Sale Of Future Royalties [Roll Forward]
Liabilities related to the sales of future royalties—beginning balance	$ 198,344				$ 0
Royalty monetization proceeds	0				274,000
Non-cash royalty revenue	(69,794)	$ (77,746)	$ (48,563)		(403,245)
Non-cash interest expense	28,911	47,313	$ 30,267		273,184
Payments to RPI	0				(10,000)
Loss on revaluation of liability related to the sale of future royalties	0				23,522
Liabilities related to the sales of future royalties – ending balance	157,461	198,344		$ 157,461	157,461
Less: unamortized transaction costs	(2,083)			(2,083)	(2,083)
Liabilities related to the sales of future royalties, net	155,378	195,427		155,378	155,378
2012 Purchase and Sale Agreement
Liability Related To Sale Of Future Royalties [Roll Forward]
Liabilities related to the sales of future royalties—beginning balance	78,282				0
Royalty monetization proceeds	0				124,000
Non-cash royalty revenue	(33,865)				(316,523)
Non-cash interest expense	10,750				234,168
Payments to RPI	0				(10,000)
Loss on revaluation of liability related to the sale of future royalties	0				23,522
Liabilities related to the sales of future royalties – ending balance	55,167	78,282		55,167	55,167
Less: unamortized transaction costs	0			0	0
Liabilities related to the sales of future royalties, net	55,167			55,167	55,167
2020 Purchase and Sale Agreement
Liability Related To Sale Of Future Royalties [Roll Forward]
Liabilities related to the sales of future royalties—beginning balance	120,062			0
Royalty monetization proceeds	0			150,000
Non-cash royalty revenue	(35,929)			(86,722)
Non-cash interest expense	18,161			39,016
Payments to RPI	0			0
Loss on revaluation of liability related to the sale of future royalties				0
Liabilities related to the sales of future royalties – ending balance	102,294	$ 120,062		102,294	102,294
Less: unamortized transaction costs	(2,083)			(2,083)	(2,083)
Liabilities related to the sales of future royalties, net	$ 100,211			$ 100,211	$ 100,211