Property, Plant and Equipment - Schedule of Property, Plant and Equipment (Details) - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021
Property, Plant and Equipment [Line Items]
Depreciable property, plant and equipment at cost	$ 154,652	$ 201,386
Less: accumulated depreciation	(124,731)	(148,039)
Depreciable property, plant and equipment, net	29,921	53,347
Construction-in-progress	2,530	7,163
Property, plant and equipment, net	32,451	60,510
Building and leasehold improvements
Property, Plant and Equipment [Line Items]
Depreciable property, plant and equipment at cost	74,889	97,385
Laboratory equipment
Property, Plant and Equipment [Line Items]
Depreciable property, plant and equipment at cost	24,243	42,704
Computer equipment and software
Property, Plant and Equipment [Line Items]
Depreciable property, plant and equipment at cost	26,205	28,829
Manufacturing equipment
Property, Plant and Equipment [Line Items]
Depreciable property, plant and equipment at cost	25,052	22,374
Furniture, fixtures, and other
Property, Plant and Equipment [Line Items]
Depreciable property, plant and equipment at cost	$ 4,263	$ 10,094