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Stock-Based Compensation (Tables)
 12 Months Ended
Dec. 31, 2022
Share-Based Payment Arrangement [Abstract]  
Schedule of Stock-Based Compensation Expense We recognize total stock-based compensation expense in our Consolidated Statements of Operations as follows (in thousands):
Year Ended December 31,
202220212020
Cost of goods sold
$2,824 $2,779 $2,825 
Research and development
27,727 54,821 57,116 
General and administrative
24,488 37,074 33,295 
Restructuring, impairment and other costs of terminated program2,281 — 1,025 
Total stock-based compensation$57,320 $94,674 $94,261 
Schedule of Black-Scholes Option-Pricing Model Assumptions Used to Calculate Fair Value of Employee Stock Options
As of December 31, 2022, shares of common stock reserved for future issuance are as follows (in thousands):
Stock options, RSUs and PSUs outstanding23,589 
Shares available for future grant under the 2017 Performance Incentive Plan2,973 
Shares available for issuance under the employee stock purchase plan841 
Total common stock reserved for issuance27,403 
The following table lists the Black-Scholes option-pricing model assumptions used to calculate the fair value of employee and director stock options, as well as the resulting grant-date fair value:
Year Ended December 31,
202220212020
Average risk-free interest rate2.9 %1.2 %0.4 %
Dividend yield0.0 %0.0 %0.0 %
Average volatility factor77.9 %63.8 %64.1 %
Weighted-average expected life5.6 years5.5 years5.6 years
Weighted-average grant-date fair value of options granted$3.18$8.07$10.70
Schedule of Stock Option Activity Under Equity Incentive Plans The table below presents a summary of stock option activity under our equity incentive plans (in thousands, except for price per share and contractual life information):
Number
of
Shares
Weighted-
Average
Exercise
Price
per Share
Weighted-
Average
Remaining
Contractual
Life
(in Years)
Aggregate
Intrinsic
Value(1)
Outstanding at December 31, 202113,542 $23.62 
Options granted
6,276 4.76 
Options exercised
(15)12.43 
Options forfeited & canceled
(5,715)20.73 
Outstanding at December 31, 202214,088 $16.40 5.71$— 
Exercisable at December 31, 20226,029 27.82 3.60$— 
_______________________________________________________________(1)Aggregate intrinsic value represents the difference between the exercise price of the option and the closing market price of our common stock on December 31, 2022.
Schedule of Restricted Stock Unit Award Activity A summary of RSU award activity is as follows (in thousands except for per share amounts):
Units IssuedWeighted-
Average
Grant
Date Fair
Value
Unvested at December 31, 20219,930 $16.80 
Granted7,708 4.14 
Vested and released(2,872)17.64 
Forfeited and canceled(5,454)15.68 
Unvested at December 31, 20229,312 $6.81