Property, Plant and Equipment (Tables)

12 Months Ended

Dec. 31, 2022

Property, Plant and Equipment [Abstract]

Schedule of Property, Plant and Equipment

Property, plant and equipment consists of the following (in thousands):

	December 31,
	2022		2021
Building and leasehold improvements	$	74,889	$	97,385
Laboratory equipment	24,243		42,704
Computer equipment and software	26,205		28,829
Manufacturing equipment	25,052		22,374
Furniture, fixtures, and other	4,263		10,094
Depreciable property, plant and equipment at cost	154,652		201,386
Less: accumulated depreciation	(124,731)		(148,039)
Depreciable property, plant and equipment, net	29,921		53,347
Construction-in-progress	2,530		7,163
Property, plant and equipment, net	$	32,451	$	60,510

We recorded the gains and losses as follows (in thousands):

	Year Ended December 31, 2022
Proceeds from sales		$	13,196
Net book value of assets		9,870
Total (gain) loss on sale or disposal of property, plan and equipment, net		(3,326)