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Property, Plant and Equipment
 12 Months Ended
Dec. 31, 2022
Property, Plant and Equipment [Abstract]  
Property, Plant and Equipment Property, Plant and Equipment
    Property, plant and equipment consists of the following (in thousands):
December 31,
20222021
Building and leasehold improvements$74,889 $97,385 
Laboratory equipment24,243 42,704 
Computer equipment and software26,205 28,829 
Manufacturing equipment25,052 22,374 
Furniture, fixtures, and other4,263 10,094 
Depreciable property, plant and equipment at cost154,652 201,386 
Less: accumulated depreciation(124,731)(148,039)
Depreciable property, plant and equipment, net29,921 53,347 
Construction-in-progress2,530 7,163 
Property, plant and equipment, net$32,451 $60,510 
    Laboratory and manufacturing equipment, including construction-in-process, include assets that support both our manufacturing and research and development activities.
Property, plant and equipment decreased significantly for the year ended December 31, 2022 as a result of our 2022 Restructuring Plan. As further disclosed in Note 11, we sold our research and development facility in India, we sold or disposed of laboratory equipment and certain computer software, and we recognized impairment charges for leasehold improvements and certain furniture and fixtures for spaces we seek to sublease.
    Depreciation and amortization expense for property, plant and equipment for the years ended December 31, 2022, 2021, and 2020 was $12.2 million, $13.0 million, and $12.5 million, respectively.