CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	3 Months Ended		9 Months Ended		129 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022
Cash flows from operating activities:
Net loss			$ (308,510)	$ (378,192)
Adjustments to reconcile net loss to net cash used in operating activities:
Non-cash royalty revenue related to the sales of future royalties			(52,167)	(58,667)	$ 385,618
Non-cash interest expense on liabilities related to the sales of future royalties	$ 6,953	$ 12,801	21,710	39,186	265,983
Change in fair value of development derivative liability	0	3,328	(33,427)	7,640
Non-cash research and development expense			4,951	11,497
Stock-based compensation	12,518	24,657	44,582	72,269
Depreciation and amortization			9,848	10,710
Impairment of right-of-use assets and property, plant and equipment	1,200		58,521	0
Amortization of premiums (discounts), net and other non-cash transactions			(372)	5,677
Changes in operating assets and liabilities:
Accounts receivable			10,960	9,895
Inventory			(3,256)	(38)
Operating leases, net			(1,423)	2,932
Other assets			4,861	814
Accounts payable			(4,184)	1,247
Accrued compensation			8,657	18,350
Other accrued expenses			(7,055)	(4,442)
Net cash used in operating activities			(246,304)	(261,122)
Cash flows from investing activities:
Purchases of investments			(295,439)	(816,049)
Maturities of investments			626,424	902,687
Sales of investments			0	5,035
Purchases of property, plant and equipment			(5,164)	(9,093)
Net cash provided by investing activities			325,821	82,580
Cash flows from financing activities:
Proceeds from shares issued under equity compensation plans			655	31,436
Cash receipts from development derivative liability			750	2,250
Net cash provided by financing activities			1,405	33,686
Effect of foreign exchange rates on cash and cash equivalents			(382)	(82)
Net increase (decrease) in cash and cash equivalents			80,540	(144,938)
Cash and cash equivalents at beginning of period			25,218	198,955
Cash and cash equivalents at end of period	$ 105,758	$ 54,017	105,758	54,017	$ 105,758
Supplemental disclosures of cash flow information:
Operating lease right-of-use asset recognized in exchange for lease liabilities			$ 0	$ 1,057