Restructuring, Impairment and Other Costs of Terminated Program - Schedule of Property, Plant and Equipment (Details) - USD ($) $ in Thousands	Sep. 30, 2022	Dec. 31, 2021
Property, Plant and Equipment [Line Items]
Property, plant and equipment, net	$ 36,803	$ 60,510
Building and leasehold improvements
Property, Plant and Equipment [Line Items]
Depreciable property, plant and equipment at cost	78,380	97,385
Laboratory equipment
Property, Plant and Equipment [Line Items]
Depreciable property, plant and equipment at cost	34,628	42,704
Computer equipment and software
Property, Plant and Equipment [Line Items]
Depreciable property, plant and equipment at cost	28,183	28,829
Manufacturing equipment
Property, Plant and Equipment [Line Items]
Depreciable property, plant and equipment at cost	23,779	22,374
Furniture, fixtures, and other
Property, Plant and Equipment [Line Items]
Depreciable property, plant and equipment at cost	4,647	10,094
Depreciable property, plant and equipment, net
Property, Plant and Equipment [Line Items]
Depreciable property, plant and equipment at cost	169,617	201,386
Less: accumulated depreciation	(135,064)	(148,039)
Property, plant and equipment, net	34,553	53,347
Construction-in-progress
Property, Plant and Equipment [Line Items]
Property, plant and equipment, net	$ 2,250	$ 7,163