CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021
Revenue:
Total revenue	$ 23,625	$ 24,921	$ 70,032	$ 76,898
Operating costs and expenses:
Cost of goods sold	4,972	5,311	15,402	18,734
Research and development	33,590	103,738	183,583	300,655
General and administrative	22,534	29,468	70,394	90,702
Restructuring, impairment and other costs of terminated program	16,830	0	124,350	0
Total operating costs and expenses	77,926	138,517	393,729	410,091
Loss from operations	(54,301)	(113,596)	(323,697)	(333,193)
Non-operating income (expense):
Change in fair value of development derivative liability	0	(3,328)	33,427	(7,640)
Non-cash interest expense on liabilities related to the sales of future royalties	(6,953)	(12,801)	(21,710)	(39,186)
Interest income and other income (expense), net	2,050	131	3,541	2,388
Total non-operating income (expense), net	(4,903)	(15,998)	15,258	(44,438)
Loss before provision for income taxes	(59,204)	(129,594)	(308,439)	(377,631)
Provision (benefit) for income taxes	(155)	112	71	561
Net loss	$ (59,049)	$ (129,706)	$ (308,510)	$ (378,192)
Basic net loss per share (in dollars per share)	$ (0.31)	$ (0.70)	$ (1.65)	$ (2.07)
Diluted net loss per share (in dollars per share)	$ (0.31)	$ (0.70)	$ (1.65)	$ (2.07)
Weighted average shares outstanding used in computing basic net loss per share (in shares)	187,641	184,110	186,767	182,736
Weighted average shares outstanding used in computing diluted net loss per share (in shares)	187,641	184,110	186,767	182,736
Product sales
Revenue:
Total revenue	$ 4,969	$ 5,194	$ 15,969	$ 17,835
Non-cash royalty revenue related to the sales of future royalties
Revenue:
Total revenue	18,342	19,413	52,167	58,667
License, collaboration and other revenue
Revenue:
Total revenue	$ 314	$ 314	$ 1,896	$ 396