Restructuring, Impairment and Other Costs of Terminated Program - Restructuring Reserve Rollforward (Details) - USD ($) $ in Thousands	3 Months Ended			9 Months Ended
	Sep. 30, 2022	Jun. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021
Restructuring Reserve [Roll Forward]
Expense recognized during the period	$ 16,830		$ 0	$ 124,350	$ 0
Employee Severance
Restructuring Cost and Reserve [Line Items]
Total severance and other termination benefits, at fair value	30,955			30,955
Restructuring Reserve [Roll Forward]
Liability balance as of March 31, 2022	14,869	$ 0
Expense recognized during the period	2,073	27,750
Payments during the period	(12,049)	(12,881)
Liability balance as of June 30, 2022	4,893	14,869		4,893
No service period
Restructuring Cost and Reserve [Line Items]
Total severance and other termination benefits, at fair value	23,000			23,000
Restructuring Reserve [Roll Forward]
Liability balance as of March 31, 2022	10,707	0
Expense recognized during the period	(588)	23,588
Payments during the period	(9,544)	(12,881)
Liability balance as of June 30, 2022	575	10,707		575
Service period required
Restructuring Cost and Reserve [Line Items]
Total severance and other termination benefits, at fair value	7,955			7,955
Restructuring Reserve [Roll Forward]
Liability balance as of March 31, 2022	4,162	0
Expense recognized during the period	2,661	4,162
Payments during the period	(2,505)	0
Liability balance as of June 30, 2022	$ 4,318	$ 4,162		$ 4,318