Liabilities Related to Sales of Future Royalties - Activity Within the Liability Account (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended		129 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Dec. 31, 2021
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Royalty monetization proceeds					$ 274,000
Non-cash royalty revenue			$ 52,167	$ 58,667	(385,618)
Non-cash interest expense	$ 6,953	$ 12,801	21,710	$ 39,186	265,983
Payments to RPI					(10,000)
Loss on revaluation of liability related to the sale of future royalties					23,522
Liabilities related to the sales of future royalties – ending balance	167,887		167,887		167,887
Less: unamortized transaction costs	(2,292)		(2,292)		(2,292)
Liabilities related to the sales of future royalties, net	165,595		165,595		165,595	$ 195,427
2012 Purchase and Sale Agreement
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Royalty monetization proceeds					124,000
Non-cash royalty revenue					(307,218)
Non-cash interest expense					232,276
Payments to RPI					(10,000)
Loss on revaluation of liability related to the sale of future royalties					23,522
Liabilities related to the sales of future royalties – ending balance	62,580		62,580		62,580
Less: unamortized transaction costs	0		0		0
Liabilities related to the sales of future royalties, net	62,580		62,580		62,580
2020 Purchase and Sale Agreement
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Royalty monetization proceeds			150,000
Non-cash royalty revenue			(78,400)
Non-cash interest expense			33,707
Payments to RPI			0
Loss on revaluation of liability related to the sale of future royalties			0
Liabilities related to the sales of future royalties – ending balance	105,307		105,307		105,307
Less: unamortized transaction costs	(2,292)		(2,292)		(2,292)
Liabilities related to the sales of future royalties, net	$ 103,015		$ 103,015		$ 103,015