Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	3 Months Ended		123 Months Ended
	Mar. 31, 2022	Mar. 31, 2021	Mar. 31, 2022
Cash flows from operating activities:
Net loss	$ (90,393)	$ (122,967)
Adjustments to reconcile net loss to net cash used in operating activities:
Non-cash royalty revenue related to the sales of future royalties	(17,561)	(18,798)	$ 351,012
Non-cash interest expense on liabilities related to the sales of future royalties	7,529	13,296	251,802
Change in fair value of development derivative liability	(33,427)	1,599
Non-cash research and development expense	4,951	2,248
Stock-based compensation	20,961	23,898
Depreciation and amortization	3,730	3,543
Amortization of premiums (discounts), net and other non-cash transactions	1,276	2,345
Changes in operating assets and liabilities:
Accounts receivable	(7,728)	9,733
Inventory	422	(1,516)
Operating leases, net	1,787	1,541
Other assets	2,864	6,183
Accounts payable	2,998	779
Accrued compensation	6,918	8,981
Other accrued expenses	7,249	(7,950)
Net cash used in operating activities	(88,424)	(77,085)
Cash flows from investing activities:
Purchases of investments	(93,493)	(295,314)
Maturities of investments	227,974	303,612
Sales of investments	0	5,036
Purchases of property, plant and equipment	(4,203)	(2,876)
Net cash provided by investing activities	130,278	10,458
Cash flows from financing activities:
Proceeds from shares issued under equity compensation plans	188	17,106
Cash receipts from development derivative liability	750	750
Net cash provided by financing activities	938	17,856
Effect of foreign exchange rates on cash and cash equivalents	(17)	(20)
Net increase (decrease) in cash and cash equivalents	42,775	(48,791)
Cash and cash equivalents at beginning of period	25,218	198,955
Cash and cash equivalents at end of period	67,993	150,164	$ 67,993
Supplemental disclosures of cash flow information:
Operating lease right-of-use asset recognized in exchange for lease liabilities	$ 0	$ 1,057