Organization and Summary of Significant Accounting Policies - Additional Information (Detail) - USD ($)		3 Months Ended
	Apr. 25, 2022	Mar. 31, 2022	Mar. 31, 2021	Dec. 31, 2021
Organization And Summary Of Significant Accounting Policies [Line Items]
Cash and investments in marketable securities		$ 704,388,000		$ 798,783,000
Accounts receivable		30,220,000		22,492,000
Allowance for credit loss		0		0
Revenue, excluding assessed tax		24,822,000	$ 23,647,000
Non-cash royalty revenue related to the sales of future royalties
Organization And Summary Of Significant Accounting Policies [Line Items]
Revenue, excluding assessed tax		17,561,000	$ 18,798,000
Subsequent Event | Employee Severance
Organization And Summary Of Significant Accounting Policies [Line Items]
Workforce termination, percentage	70.00%
Bristol Myers Squibb Collaboration Agreement
Organization And Summary Of Significant Accounting Policies [Line Items]
Accounts receivable		$ 26,900,000		$ 21,400,000