Income Taxes - Additional Information (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Income Taxes Disclosure [Line Items]
Valuation allowance, increase (decrease) amount	$ (115,600)	$ 95,000
Income tax research credits	4,727	3,081	$ 10,511
Unrecognized tax benefits, interest recognized	0	0	0
Unrecognized tax benefits, penalties recognized	$ 0	$ 0	$ 0
Unrecognized tax benefits, period may increase or decrease due to tax examination	12 months
Federal
Income Taxes Disclosure [Line Items]
Net operating loss carryforward for income tax	$ 2,400,000
Income tax research credits	103,300
Federal orphan drug credits	19,400
State
Income Taxes Disclosure [Line Items]
Net operating loss carryforward for income tax	1,500,000
Income tax research credits	$ 47,000