Liabilities Related to the Sales of Future Royalties - Additional Information (Details) $ in Thousands				1 Months Ended		3 Months Ended	12 Months Ended
	Dec. 30, 2020 USD ($)	Dec. 16, 2020 USD ($)	Feb. 24, 2012 USD ($)	Mar. 31, 2014 USD ($)	Mar. 31, 2013 USD ($)	Dec. 31, 2021 USD ($)	Dec. 31, 2021 USD ($)	Dec. 31, 2020 USD ($)	Dec. 31, 2019 USD ($)
Liability Related to the Sale of Future Royalties [Line Items]
Loss on revaluation of liability related to the sale of future royalties							$ 24,410	$ 0	$ 0
2012 Purchase and Sale Agreement
Liability Related to the Sale of Future Royalties [Line Items]
Proceeds from sale of royalty rights			$ 124,000
2012 Purchase and Sale Agreement | Future Royalties
Liability Related to the Sale of Future Royalties [Line Items]
Fair value of liabilities						$ 84,700	$ 84,700
Loss on revaluation of liability related to the sale of future royalties						23,500
Transaction costs related to revised royalty payments						$ 900
2012 Purchase and Sale Agreement | Future Royalties | Measurement Input, Discount Rate
Liability Related to the Sale of Future Royalties [Line Items]
Royalties liability, measurement input						0.160	0.160
2020 Purchase and Sale Agreement
Liability Related to the Sale of Future Royalties [Line Items]
Proceeds from sale of royalty rights	$ 150,000
Payment of transaction related to purchase and sale agreement		$ 210,000
Payment of transaction related to purchase and sale agreement if threshold is not achieved		240,000
Minimum transaction royalties payments needed to pay the difference between the 2025 threshold and 2020 transaction royalties		$ 208,000
Transaction costs related to sale of potential future royalties	$ 3,800
2020 Purchase and Sale Agreement | Measurement Input, Interest Rate
Liability Related to the Sale of Future Royalties [Line Items]
Royalties liability, measurement input						0.15	0.15
Pursuant to the 2012 Purchase and Sale Agreement
Liability Related to the Sale of Future Royalties [Line Items]
Payment made for milestone not achieved year two				$ 7,000
Payment made for milestone not achieved year one					$ 3,000