Property, Plant and Equipment - Schedule of Property, Plant and Equipment (Details) - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020
Property, Plant and Equipment [Line Items]
Depreciable property, plant and equipment at cost	$ 201,386	$ 193,450
Less: accumulated depreciation	(148,039)	(138,488)
Depreciable property, plant and equipment, net	53,347	54,962
Construction-in-progress	7,163	4,700
Property, plant and equipment, net	60,510	59,662
Building and leasehold improvements
Property, Plant and Equipment [Line Items]
Depreciable property, plant and equipment at cost	97,385	92,977
Laboratory equipment
Property, Plant and Equipment [Line Items]
Depreciable property, plant and equipment at cost	42,704	40,121
Computer equipment and software
Property, Plant and Equipment [Line Items]
Depreciable property, plant and equipment at cost	28,829	28,684
Manufacturing equipment
Property, Plant and Equipment [Line Items]
Depreciable property, plant and equipment at cost	22,374	21,796
Furniture, fixtures, and other
Property, Plant and Equipment [Line Items]
Depreciable property, plant and equipment at cost	$ 10,094	$ 9,872