Selected Quarterly Financial Data (Tables)

12 Months Ended

Dec. 31, 2021

Quarterly Financial Information Disclosure [Abstract]

Schedule of Quarterly Financial Data

The following table sets forth certain unaudited quarterly financial data. In our opinion, the unaudited information set forth below has been prepared on the same basis as our audited information and includes all adjustments necessary to present fairly the information set forth herein. We have experienced fluctuations in our quarterly results and expect these fluctuations to continue in the future. Due to these and other factors, we believe that quarter-to-quarter comparisons of our operating results will not be meaningful, and the results for any one quarter may not be indicative of our future performance. All data is in thousands except per share information.

	Year Ended December 31, 2021								Year Ended December 31, 2020
	Q1		Q2		Q3		Q4		Q1		Q2		Q3		Q4
Product sales	$	4,795	$	7,846	$	5,194	$	5,890	$	3,444	$	5,485	$	5,691	$	2,884
Total revenue	$	23,647	$	28,330	$	24,921	$	25,009	$	50,573	$	48,847	$	30,033	$	23,462
Cost of goods sold	$	5,756	$	7,667	$	5,311	$	6,163	$	3,811	$	5,773	$	5,570	$	4,323
Research and development expenses	$	95,604	$	101,313	$	103,738	$	99,614	$	108,987	$	96,436	$	100,531	$	102,724
Operating loss	$	(109,392)	$	(110,205)	$	(113,596)	$	(112,910)	$	(133,631)	$	(77,709)	$	(103,050)	$	(110,721)
Net loss	$	(122,967)	$	(125,519)	$	(129,706)	$	(145,645)	$	(138,651)	$	(80,000)	$	(108,586)	$	(117,203)
Net loss per share, basic and diluted(1)	$	(0.68)	$	(0.69)	$	(0.70)	$	(0.79)	$	(0.78)	$	(0.45)	$	(0.61)	$	(0.65)

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(1)Quarterly loss per share amounts may not total to the year-to-date loss per share due to rounding.