Property, Plant and Equipment (Tables)

12 Months Ended

Dec. 31, 2021

Property, Plant and Equipment [Abstract]

Schedule of Property, Plant and Equipment

Property, plant and equipment consists of the following (in thousands):

	December 31,
	2021		2020
Building and leasehold improvements	$	97,385	$	92,977
Laboratory equipment	42,704		40,121
Computer equipment and software	28,829		28,684
Manufacturing equipment	22,374		21,796
Furniture, fixtures, and other	10,094		9,872
Depreciable property, plant and equipment at cost	201,386		193,450
Less: accumulated depreciation	(148,039)		(138,488)
Depreciable property, plant and equipment, net	53,347		54,962
Construction-in-progress	7,163		4,700
Property, plant and equipment, net	$	60,510	$	59,662