Property, Plant and Equipment

12 Months Ended

Dec. 31, 2021

Property, Plant and Equipment [Abstract]

Property, Plant and Equipment

Property, Plant and Equipment

    Property, plant and equipment consists of the following (in thousands):

	December 31,
	2021		2020
Building and leasehold improvements	$	97,385	$	92,977
Laboratory equipment	42,704		40,121
Computer equipment and software	28,829		28,684
Manufacturing equipment	22,374		21,796
Furniture, fixtures, and other	10,094		9,872
Depreciable property, plant and equipment at cost	201,386		193,450
Less: accumulated depreciation	(148,039)		(138,488)
Depreciable property, plant and equipment, net	53,347		54,962
Construction-in-progress	7,163		4,700
Property, plant and equipment, net	$	60,510	$	59,662

    Building and leasehold improvements include our manufacturing, research and development and administrative facilities and the related improvements to these facilities. Laboratory and manufacturing equipment include assets that support both our manufacturing and research and development efforts. Construction-in-progress includes assets being built to enhance our manufacturing and research and development efforts.

    Depreciation and amortization expense for property, plant and equipment for the years ended December 31, 2021, 2020, and 2019 was $13.0 million, $12.5 million, and $11.0 million, respectively.