Condensed Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2021	Jun. 30, 2020	Jun. 30, 2021	Jun. 30, 2020
Revenue:
Total revenue	$ 28,330	$ 48,847	$ 51,977	$ 99,420
Operating costs and expenses:
Cost of goods sold	7,667	5,773	13,423	9,584
Research and development	101,313	96,436	196,917	205,423
General and administrative	29,555	24,347	61,234	50,564
Impairment of assets and other costs for terminated program	0	0	0	45,189
Total operating costs and expenses	138,535	126,556	271,574	310,760
Loss from operations	(110,205)	(77,709)	(219,597)	(211,340)
Non-operating income (expense):
Non-cash interest expense on liability related to sale of future royalties	(13,089)	(6,691)	(26,385)	(13,659)
Change in fair value of development derivative liability	(2,713)	0	(4,312)	0
Interest income and other income (expense), net	845	5,191	2,257	13,543
Interest expense	0	(647)	0	(6,851)
Total non-operating income (expense), net	(14,957)	(2,147)	(28,440)	(6,967)
Loss before provision for income taxes	(125,162)	(79,856)	(248,037)	(218,307)
Provision for income taxes	357	144	449	344
Net loss	$ (125,519)	$ (80,000)	$ (248,486)	$ (218,651)
Basic net loss per share (in dollars per share)	$ (0.69)	$ (0.45)	$ (1.37)	$ (1.23)
Diluted net loss per share (in dollars per share)	$ (0.69)	$ (0.45)	$ (1.37)	$ (1.23)
Weighted average shares outstanding used in computing basic net loss per share (in shares)	182,698	178,327	182,038	177,755
Weighted average shares outstanding used in computing diluted net loss per share (in shares)	182,698	178,327	182,038	177,755
Product sales
Revenue:
Total revenue	$ 7,846	$ 5,485	$ 12,641	$ 8,929
Royalty revenue
Revenue:
Total revenue	0	9,403	0	19,122
Non-cash royalty revenue related to sale of future royalties
Revenue:
Total revenue	20,456	7,684	39,254	17,579
License, collaboration and other revenue
Revenue:
Total revenue	$ 28	$ 26,275	$ 82	$ 53,790