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Stock-Based Compensation (Tables)
6 Months Ended
Jun. 30, 2021
Share-based Payment Arrangement [Abstract]  
Stock-Based Compensation Expense We recognized total stock-based compensation expense in our Condensed Consolidated Statements of Operations as follows (in thousands):
Three months ended June 30, Six months ended June 30,
2021202020212020
Cost of goods sold
$716 $664 $1,443 $1,424 
Research and development
13,479 14,161 27,641 29,614 
General and administrative
9,519 8,546 18,528 16,544 
Impairment of assets and other costs for terminated program— — — 1,025 
Total stock-based compensation$23,714 $23,371 $47,612 $48,607 
Share-based Compensation, Activity We issued stock-based awards and resulting shares of our common stock as follows (shares in thousands):
Three months ended June 30, Six months ended June 30,
2021202020212020
Options granted
157 — 278 49 
Weighted-average grant-date fair value of options granted
$9.78 $— $10.23 $11.88 
RSUs granted
520 275 887 520 
Weighted-average grant-date fair value of RSUs granted
$18.20 $21.65 $19.21 $20.36 
Shares issued under equity compensation plans
1,483 947 3,682 2,305