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Cash and Investments in Marketable Securities (Tables)
 6 Months Ended
Jun. 30, 2021
Fair Value Disclosures [Abstract]  
Cash and Investments in Marketable Securities, Including Cash Equivalents Cash and investments in marketable securities, including cash equivalents, are as follows (in thousands):
Estimated Fair Value at
June 30, 2021December 31, 2020
Cash and cash equivalents$152,345 $198,955 
Short-term investments847,720 862,941 
Long-term investments57,397 136,662 
Total cash and investments in marketable securities$1,057,462 $1,198,558 
Portfolio of Cash and Investments in Marketable Securities Our portfolio of cash and investments in marketable securities includes (in thousands):
June 30, 2021December 31, 2020
Amortized CostGross Unrealized GainsGross Unrealized LossesFair ValueFair Value
Corporate notes and bonds$403,490 $152 $(91)$403,551 $687,469 
Corporate commercial paper487,414 51 (35)487,430 313,497 
Obligations of U.S. government agencies5,880 2 (1)5,881 2,382 
Available-for-sale investments$896,784 $205 $(127)$896,862 $1,003,348 
Money market funds138,289 179,302 
Certificates of deposit8,255 9,623 
Cash14,056 6,285 
Total cash and investments in marketable securities$1,057,462 $1,198,558