Property, Plant and Equipment - Property, Plant and Equipment (Detail) - USD ($) $ in Thousands	Dec. 31, 2019	Dec. 31, 2018
Property, Plant and Equipment [Line Items]
Depreciable property, plant and equipment at cost	$ 188,322	$ 164,270
Less: accumulated depreciation	(127,875)	(120,507)
Depreciable property, plant and equipment, net	60,447	43,763
Construction-in-progress	4,552	5,088
Property, plant and equipment, net	64,999	48,851
Building and leasehold improvements
Property, Plant and Equipment [Line Items]
Depreciable property, plant and equipment at cost	93,097	77,771
Laboratory equipment
Property, Plant and Equipment [Line Items]
Depreciable property, plant and equipment at cost	36,623	33,806
Computer equipment and software
Property, Plant and Equipment [Line Items]
Depreciable property, plant and equipment at cost	26,910	23,395
Manufacturing equipment
Property, Plant and Equipment [Line Items]
Depreciable property, plant and equipment at cost	22,030	21,339
Furniture, fixtures, and other
Property, Plant and Equipment [Line Items]
Depreciable property, plant and equipment at cost	$ 9,662	$ 7,959