Property, Plant and Equipment (Tables)

12 Months Ended

Dec. 31, 2019

Property, Plant and Equipment [Abstract]

Property, Plant and Equipment

Property, plant and equipment consists of the following (in thousands):

	December 31,
	2019			2018
Building and leasehold improvements	$	93,097		$	77,771
Laboratory equipment	36,623			33,806
Computer equipment and software	26,910			23,395
Manufacturing equipment	22,030			21,339
Furniture, fixtures, and other	9,662			7,959
Depreciable property, plant and equipment at cost	188,322			164,270
Less: accumulated depreciation	(127,875		)	(120,507		)
Depreciable property, plant and equipment, net	60,447			43,763
Construction-in-progress	4,552			5,088
Property, plant and equipment, net	$	64,999		$	48,851