Condensed Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2019	Sep. 30, 2018	Sep. 30, 2019	Sep. 30, 2018
Revenue:
Total revenue	$ 29,218	$ 27,762	$ 80,755	$ 1,153,497
Operating costs and expenses:
Cost of goods sold	4,927	4,783	15,385	16,951
Research and development	99,048	102,895	324,197	290,653
General and administrative	23,983	18,718	71,570	57,666
Total operating costs and expenses	127,958	126,396	411,152	365,270
Income (loss) from operations	(98,740)	(98,634)	(330,397)	788,227
Non-operating income (expense):
Interest expense	(5,425)	(5,442)	(15,882)	(16,167)
Non-cash interest expense on liability related to sale of future royalties	(5,813)	(4,814)	(17,853)	(14,808)
Interest income and other income (expense), net	11,492	11,847	35,964	25,523
Total non-operating income (expense), net	254	1,591	2,229	(5,452)
Income (loss) before provision for income taxes	(98,486)	(97,043)	(328,168)	782,775
Provision (benefit) for income taxes	322	(900)	(939)	3,250
Net income (loss)	$ (98,808)	$ (96,143)	$ (327,229)	$ 779,525
Net income (loss) per share
Basic (in dollars per share)	$ (0.56)	$ (0.56)	$ (1.87)	$ 4.63
Diluted (in dollars per share)	$ (0.56)	$ (0.56)	$ (1.87)	$ 4.34
Weighted average shares outstanding used in computing net income (loss) per share
Basic (in shares)	175,402	172,698	174,609	168,363
Diluted (in shares)	175,402	172,698	174,609	179,619
Product sales
Revenue:
Total revenue	$ 5,558	$ 4,256	$ 14,302	$ 16,414
Royalty revenue
Revenue:
Total revenue	10,275	10,259	29,008	29,898
Non-cash royalty revenue related to sale of future royalties
Revenue:
Total revenue	10,264	8,372	27,585	24,337
License, collaboration and other revenue
Revenue:
Total revenue	$ 3,121	$ 4,875	$ 9,860	$ 1,082,848