EXHIBIT 32.1

CERTIFICATION OF CHIEF EXECUTIVE OFFICER PURSUANT TO
18 U.S.C. SECTION 1350,
AS ADOPTED PURSUANT TO
SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

     In connection with the Annual Report of ProxyMed, Inc. d/b/a MedAvant Healthcare Solutions (the “Company”) on Form 10-K for the period ending December 31, 2007 as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I, Peter E. Fleming, III, certify, pursuant to 18 U.S.C. ss. 1350, as adopted pursuant to ss. 906 of the Sarbanes-Oxley Act of 2002, that:

     (1) The Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and

     (2) The information contained in the Report fairly presents, in all material respects, the financial condition and result of operations of the
Company.

/s/ PETER E. FLEMING, III                        

Peter E. Fleming, III
Interim Chief Executive Officer
April 15, 2008

A signed original of this written statement required by Section 906 has been provided to ProxyMed, Inc. d/b/a MedAvant Healthcare Solutions and will be retained by ProxyMed, Inc. and furnished to the Securities and Exchange Commission or its staff upon request.