EXHIBIT 5.1


                          [HOLLAND & KNIGHT LETTERHEAD]


                                  April 7, 2006

ProxyMed, Inc. d/b/a MedAvant Healthcare Solutions
1854 Shackleford Court
Suite 200
Atlanta, Georgia 30093

         Re:      Registration Statement on Form S-1 (File No. 333-131333)

Ladies and Gentlemen:

         We have acted as counsel to ProxyMed, Inc., d/b/a MedAvant Healthcare
Solutions, a Florida corporation (the "Company"), in connection with the
Company's Registration Statement on Form S-1, File No. 333-131333, as filed with
the Securities and Exchange Commission (the "Commission") on January 27, 2006
(such Registration Statement, as so amended, being hereinafter referred to as
the "Registration Statement"), for the purpose of registering with the
Commission under the Securities Act of 1933, as amended (the "Securities Act"),
up to 1,216,968 shares (the "Shares") of common stock of the Company, par value
$0.001 per share (the "Common Stock"), of which (a) 500,000 shares were issued
on December 7, 2005 to Laurus Master Fund, Ltd. (the "Laurus Shares") pursuant
to that certain Security and Purchase Agreement among the Company, certain of
its subsidiaries, and Laurus, dated December 7, 2005 (the "Purchase Agreement"),
and (ii) 716,968 shares (the "MedUnite Shares") may be issued upon the
conversion of certain 4% convertible promissory notes (the "Notes") issued in
connection with the acquisition by the Company of all of the stock of MedUnite,
Inc. ("MedUnite") on December 31, 2002, pursuant to the Agreement and Plan of
Merger among the Company, Davie Acquisition Corp., and MedUnite (the "Merger
Agreement").

         This opinion letter is delivered in accordance with the requirements of
Item 601(b)(5) of Regulation S-K under the Securities Act.

         In connection with the foregoing registration, we have acted as counsel
for the Company, and have examined originals, or copies certified to our
satisfaction of all such corporate records of the Company, certificates of
public officials and representatives of the Company, and other documents as we
deemed it necessary to require as a basis for the opinion hereafter expressed.

         In our examination, we have assumed the legal capacity of all natural
persons, the genuineness of all signatures, the authenticity of all documents
submitted to us as originals, the conformity to original documents of all
documents submitted to us as certified or photostatic copies, and the
authenticity of the originals of such latter documents. In making our
examination of documents executed or to be executed by parties other than the
Company, we have assumed





that such parties had or will have the power,  corporate or other, to enter into
and  perform  all  obligations  thereunder,  and we have  also  assumed  the due
authorization  by all requisite  action,  corporate or other,  the execution and
delivery by such parties of such  documents and the validity and binding  effect
thereof. As to any facts material to the opinions expressed herein which we have
not  independently  established or verified,  we have relied upon statements and
representations  of  officers  and other  representatives  of the  Company,  and
others.

         Based on the foregoing, and having regard for legal considerations that
we deem relevant, it is our opinion that (i) the Laurus Shares are duly
authorized, legally issued, fully paid and nonassessable; and (ii) upon issuance
of the MedUnite Shares in the manner contemplated by the Notes, the Merger
Agreement and the Indenture between the Company and LaSalle Bank National
Association, dated December 31, 2002, and assuming no change in relevant facts,
the MedUnite Shares will be duly authorized, legally issued, fully paid and
nonassessable.

         The foregoing opinion is limited to the federal laws of the United
States and the Florida Business Corporation Act, and we express no opinion as to
the effect of the laws of any other jurisdiction. We hereby consent to the
filing of this opinion as Exhibit 5.1 to the Registration Statement and to the
reference to our firm under the caption "Legal Matters" in the Registration
Statement. In giving such consent, we do not admit that we are within the
category of persons whose consent is required under Section 7 of the Securities
Act or the rules and regulations of the Commission.


                                                               Very Truly Yours,

                                                        /s/ Holland & Knight LLP

                                                            Holland & Knight LLP