X0306 4 2021-12-16 0 0000090498 SIMMONS FIRST NATIONAL CORP SFNC 0001628516 Massanelli Stephen C C/O SIMMONS FIRST NATIONAL CORP. 501 MAIN STREET PINE BLUFF AR 71601 0 1 0 0 EVP Common Stock 2021-12-16 4 M 0 3134 29.46 A 51987 D Common Stock 2021-12-16 4 F 0 1387 29.46 D 50600 D Restricted Stock Unit 29.46 2021-12-16 4 M 0 3134 0 D Common 3134 3135 D The Restricted Stock Unit vested on December 16, 2021. Shares will be delivered within 30 days of vesting. 3,135 Restricted Stock Units vest on December 16, 2022. SFNC shares will be delivered within 30 days of vesting. Events such as retirement, death, disability and other specified events in the agreement may result in earlier vesting. /s/ Stephen C. Massanelli by Natalie Gassiott 2021-12-17