X0306 4 2018-02-24 0 0000090498 SIMMONS FIRST NATIONAL CORP SFNC 0001235478 MAKRIS GEORGE JR SIMMONS FIRST NATIONAL CORP. 501 MAIN STREET PINE BLUFF AR 71601 1 1 0 0 Chairman & CEO SFNC 2018-02-24 4 F 0 845 29.20 D 124197 D SFNC 210766 D SFNC 1016 D SFNC 1796 D SFNC 3742 I By Trust SFNC 8100 I By IRA SFNC 9500 I By IRA (Spouse) SFNC 134 I By IRA On February 8, 2018, the Company effected a 2-for-1 stock split. The number of shares reported in this Form 4 has been adjusted to reflect the stock split. /s/ George Makris, Jr. by Piper P. Erwin 2018-02-27