X0201 42003-12-291 0000904973 GTC BIOTHERAPEUTICS INC GTCB 0001241322 MEADE HARRY C/O GTC BIOTHERAPEUTICS, INC. 175 CROSSING BOULEVARD FRAMINGHAM MA 01702 0100SVP, Transgenic ResearchCommon Stock2003-12-295J05242.533A939.1643IBy SonCommon Stock8569.3174IBy 401(k) PlanCommon Stock34226DShares acquired by his adult son through Issuer's Employee Stock Purchase Plan, a Rule 16b-3 plan. The reporting person disclaims beneficial ownership of these shares of common stock held indirectly by his adult son, and this report shall not be deemed an admission that the reporting person is the beneficial owner of such securities for purposes of Section 16 or any other purpose.Harry M. Meade2003-12-30