X0202 4 2004-12-09 0000904973 GTC BIOTHERAPEUTICS INC GTCB 0001242331 LIPOSKY GREGORY F C/O GTC BIOTHERAPEUTICS, INC. 175 CROSSING BOULEVARD FRAMINGHAM MA 01702 0 1 0 0 SVP, Operations Common Stock (right to buy) 2.25 2004-12-09 4 A 0 1000 0 A 2014-12-08 Common Stock 1000 1000 D 200 options vested on December 9, 2004, the remaining 800 options vest in equal annual installments on each of December 9, 2005, 2006, 2007 and 2008, subject to possible acceleration upon the satisfaction of certain conditions. Nathaniel S. Gardiner as attorney-in-fact for Gregory Liposky 2004-12-13