X0303 4 2009-09-25 0000904973 GTC BIOTHERAPEUTICS INC GTCB 0001384030 Bechon Christian C/O GTC BIOTHERAPEUTICS, INC. 175 CROSSING BOULEVARD FRAMINGHAM MA 01702 1 0 1 0 Common Stock 2009-09-25 4 A 0 2844 1.758 A 13348 D Common Stock 2014840 I See Foonote Shares acquired at Mr. Bechon's election to receive common stock in lieu of the quarterly cash payment of his 2009 director retainer fees and issued pursuant to GTC's 2002 Equity Incentive Plan. The shares are held by LFB Biotechnologies, S.A.S. Mr. Bechon is the President Directeur General of LFB Biotechnologies, S.A.S. Mr. Bechon disclaims beneficial ownership of all securities held by LFB Biotechnologies, S.A.S. /s/ Nathaniel S. Gardiner as attorney-in-fact for Christian Bechon 2009-09-28