X0303 4 2009-06-30 0000904973 GTC BIOTHERAPEUTICS INC GTCB 0001356201 Scotland Richard A C/O GTC BIOTHERAPEUTICS, INC. 175 CROSSING BOULEVARD FRAMINGHAM MA 01702 0 1 0 0 Senior VP, Regulatory Affairs Common Stock 2009-06-30 4 F 0 1165 2.66 D 10631 D Common Stock 4603 I By 401(k) The shares reported were withheld to pay a tax liability in connection with the vesting of restricted stock units, which units were previously reported on a prior Form 4 filed by Mr. Scotland. On May 26, 2009 the issuer effected a one-for-ten reverse stock split of its outstanding common stock, resulting in the reporting person owning 106,178 fewer shares of common stock. On May 26, 2009 the issuer effected a one-for-ten reverse stock split of its outstanding common stock, resulting in the reporting person owning 41,436 fewer shares of common stock in his 401(k). /s/ Nathaniel S. Gardiner as attorney-in-fact for Richard A. Scotland 2009-07-01