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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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<SEC-DOCUMENT>0000908662-09-000246.txt : 20090629
<SEC-HEADER>0000908662-09-000246.hdr.sgml : 20090629
<ACCEPTANCE-DATETIME>20090629185529
ACCESSION NUMBER:		0000908662-09-000246
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20090626
FILED AS OF DATE:		20090629
DATE AS OF CHANGE:		20090629

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			GTC BIOTHERAPEUTICS INC
		CENTRAL INDEX KEY:			0000904973
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				043186494
		STATE OF INCORPORATION:			MA
		FISCAL YEAR END:			0101

	BUSINESS ADDRESS:	
		STREET 1:		175 CROSSING BLVD
		CITY:			FRAMINGHAM
		STATE:			MA
		ZIP:			01701
		BUSINESS PHONE:		508620-970

	MAIL ADDRESS:	
		STREET 1:		175 CROSSING BLVD
		CITY:			FRAMINGHAM
		STATE:			MA
		ZIP:			01701

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			MILLER MARVIN
		CENTRAL INDEX KEY:			0001239737

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-21794
		FILM NUMBER:		09917556

	MAIL ADDRESS:	
		STREET 1:		GTC BIOTHERAPEUTICS, INC.
		STREET 2:		175 CROSSING BOULEVARD
		CITY:			FRAMINGHAM
		STATE:			MA
		ZIP:			01702
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>edgar.xml
<DESCRIPTION>PRIMARY DOCUMENT
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0303</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2009-06-26</periodOfReport>

    <issuer>
        <issuerCik>0000904973</issuerCik>
        <issuerName>GTC BIOTHERAPEUTICS INC</issuerName>
        <issuerTradingSymbol>GTCB</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001239737</rptOwnerCik>
            <rptOwnerName>MILLER MARVIN</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O GTC BIOTHERAPEUTICS, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>175 CROSSING BOULEVARD</rptOwnerStreet2>
            <rptOwnerCity>FRAMINGHAM</rptOwnerCity>
            <rptOwnerState>MA</rptOwnerState>
            <rptOwnerZipCode>01702</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2009-06-26</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>444</value>
                    <footnoteId id="F1"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>2.70</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>2902</value>
                    <footnoteId id="F2"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value></value>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">Shares acquired at Mr. Miller's election to receive common stock in lieu of the quarterly cash payment of his 2009 director retainer fees and issued pursuant to GTC's 2002 Equity Incentive Plan.</footnote>
        <footnote id="F2">On May 26, 2009 the issuer effected a one-for-ten reverse stock split of its outstanding common stock, resulting in the reporting person owning 22,126 fewer shares of common stock.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>/s/ Nathaniel S. Gardiner as attorney-in-fact for Marvin L. Miller</signatureName>
        <signatureDate>2009-06-29</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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