X0202 3/A 2006-03-10 2006-03-14 0 0000904973 GTC BIOTHERAPEUTICS INC GTCB 0001356201 Scotland Richard A C/O GTC BIOTHERAPEUTICS, INC. 175 CROSSING BOULEVARD FRAMINGHAM MA 01702 0 1 0 0 Senior VP, Regulatory Affairs Common Stock 19163 D Common Stock 5957 I By 401(k) Plan Common Stock (Right to Buy) .88 2012-07-29 Common Stock 20000 D Common Stock (Right to Buy) 1.45 2013-02-14 Common Stock 30000 D Common Stock (Right to Buy) 3.96 2014-02-13 Common Stock 23386 D Common Stock (Right to Buy) 3.96 2005-12-22 2014-02-13 Common Stock 1614 D Common Stock (Right to Buy) 2.25 2014-12-09 Common Stock 1000 D Common Stock (Right to Buy) 2.25 2014-12-09 Common Stock 9000 D Common Stock (Right to Buy) 1.71 2015-02-15 Common Stock 35000 D Reflects a reduction of 24,653 shares erroneously included in original filing. 4,000 options vested on each of July 29, 2002, 2003, 2004 and 2005. The remaining 4,000 options vest on July 29, 2006. 6,000 options vested on each of February 14, 2003, 2004, 2005 and 2006. The remaining 6,000 options vest on February 14, 2007. 5,000 options vested on each of February 13, 2004 and 2005. 13,386 options vested on December 22, 2005. 200 options vested on each of December 9, 2004 and 2005. The remaining 600 options vest in equal annual installments on each of December 9, 2006, 2007 and 2008. 1,800 options vested on each of December 9, 2004 and 2005. The remaining 5,400 options vest in equal annual installments on each of December 9, 2006, 2007 and 2008. 7,000 options vested on each of February 15, 2005 and 2006. The remaining 21,000 options vest in equal annual installments on each of February 15, 2007, 2008 and 2009. Richard A. Scotland 2006-03-21