X0306 4 2016-10-14 0 0001260990 GTX INC /DE/ GTXI 0000903352 HYDE JOSEPH R III 175 TOYOTA PLAZA 7TH FLOOR MEMPHIS TN 38103 1 0 1 0 Common Stock 2016-10-14 4 A 0 7716049 .81 A 43191009.21 D Common Stock 216462 I By Spouse Common Stock 1956540 I By 2015-1 GRAT Common Stock 978270 I By 2015-2 GRAT Common Stock 652180 I By 2015-3 GRAT Common Stock 1956540 I By 2015-4 GRAT Common Stock 1956540 I By 2015-5 GRAT Common Stock 200430 I By 2014-4 GRAT Common Stock 13361 I By 2014-5 GRAT Common Stock 13361 I By 2014-6 GRAT Common Stock 508904 I By Trust Common Stock 508903 I By Trust Common Stock 508903 I By Trust Common Stock 203791 I By Trust Common Stock 114350 I By Trust Common Stock 145352 I By Pittco Associates III, L.P. Common Stock 3915716 I By Pittco Investments, L.P. The reporting person disclaims beneficial ownership of these securities except to the extent of his pecuniary interest therin, and the inclusion of these shares in his report shall not be deemed an admission of beneficial ownership of the reported shares for the purpose of Section 16 or any other purpose. Pittco Associates II, L.P., a limited partnership of which the reporting person is the sole general partner, held the reported securities until July 2015, at which time the reported securities were transferred to Pittco Associates III, L.P., a limited partnership of which the reporting person is the sole general partner. The transfer effected only a change in the form of beneficial ownership; it did not change the reporting person's pecuniary interest in the reported securities. /s/ Henry P. Doggrell, by Power of Attorney 2016-10-17