The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL
OMB Number:3235-0006
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COLUMN 1COLUMN 2COLUMN 3COLUMN 4COLUMN 5COLUMN 6COLUMN 7COLUMN 8
VALUESHRS ORSH/PUT/INVESTMENTOTHERVOTING AUTHORITY
NAME OF ISSUERTITLE OF CLASSCUSIP(x$1000)PRN AMTPRNCALLDISCRETIONMANAGERSOLESHAREDNONE
10X GENOMICS INCCL A COM88025U10985,856688,611SH DFND 00688,611
1LIFE HEALTHCARE INCCOM68269G107117,8734,156,309SH DFND 004,156,309
2U INCCOM90214J1011,93257,051SH DFND 0057,051
89BIO INCCOM28255910382732,248SH DFND 0032,248
ABIOMED INCCOM00365410035,512128,174SH DFND 00128,174
ACCEL ENTERTAINMENT INCCOM CL A100436Q106262,400SH DFND 002,400
ACCOLADE INCCOM00437E10250,9651,311,157SH DFND 001,311,157
ACTIVISION BLIZZARD INCCOM00507V1091,68420,806SH DFND 0020,806
ADAPTIVE BIOTECHNOLOGIES CORCOM00650F109116,5802,397,279SH DFND 002,397,279
ADOBE SYSTEMS INCORPORATEDCOM00724F10160,473123,306SH DFND 00123,306
ADYEN NV 144ACOMN3501V10460,87933,015SH DFND 0033,015
AFYA LTDCL A COMG011251066,798249,551SH DFND 00249,551
AGORA INCADS00851L10311,045256,982SH DFND 00256,982
ALAMOS GOLD INC NEWCOM CL A0115321084,604522,620SH DFND 00522,620
ALASKA COMMUNICATIONS SYS GRCOM01167P1011,888943,833SH DFND 00943,833
ALECTOR INCCOM01444210722,7752,161,820SH DFND 002,161,820
ALIBABA GROUP HLDG LTDSPONSORED ADS01609W102125,324426,302SH DFND 00426,302
ALLAKOS INCCOM01671P1003,54843,564SH DFND 0043,564
ALLOGENE THERAPEUTICS INCCOM0197701062,33161,816SH DFND 0061,816
ALLOVIR INCCOM01981810338013,829SH DFND 0013,829
ALNYLAM PHARMACEUTICALS INCCOM02043Q107129,645890,416SH DFND 00890,416
ALPHABET INCCAP STK CL A02079K30558,80740,125SH DFND 0040,125
ALPHABET INCCAP STK CL C02079K10767,51645,942SH DFND 0045,942
ALTERYX INCCOM CL A02156B103330SH DFND 0030
ALTUS MIDSTREAM COCOM NEW CL A02215L20964457,929SH DFND 0057,929
AMAZON COM INCCOM023135106497,665158,053SH DFND 00158,053
AMERICAN TOWER CORP NEWCOM03027X10018,31375,758SH DFND 0075,758
AMERICAN WELL CORPCL A03044L1052,95199,561SH DFND 0099,561
AMICUS THERAPEUTICS INCCOM03152W10929,4372,084,742SH DFND 002,084,742
AMYRIS INCCOM NEW03236M20015051,369SH DFND 0051,369
ANAPLAN INCCOM03272L108341SH DFND 0041
ANTERIX INCCOM03676C1001,50846,117SH DFND 0046,117
APACHE CORPCOM0374111051,542162,809SH DFND 00162,809
APPFOLIO INCCOM CL A03783C10063,081444,827SH DFND 00444,827
APPIAN CORPCL A03782L1011,60024,709SH DFND 0024,709
APPLE INCCOM03783310019,997172,667SH DFND 00172,667
APPLIED OPTOELECTRONICS INCCOM03823U102797,050SH DFND 007,050
APTOSE BIOSCIENCES INCCOM NEW03835T2001125SH DFND 00125
ARCUS BIOSCIENCES INCCOM03969F10914,923870,634SH DFND 00870,634
ARENA PHARMACEUTICALS INCCOM NEW04004760748,101643,147SH DFND 00643,147
ARGENX SESPONSORED ADR04016X10135,907136,779SH DFND 00136,779
ARISTA NETWORKS INCCOM0404131066,26430,269SH DFND 0030,269
ARITZIA INC SUB VTG SHS ISIN CA04045U1021 SEDOL BDCG2C2COM04045U10210,025768,271SH DFND 00768,271
ARVINAS INCCOM04335A10531,2891,325,260SH DFND 001,325,260
ASHTEAD GROUP ORD GBP010 ISIN GB0000536739 SEDOL 0053673COMG05320109385SH DFND 0085
ATLASSIAN CORP PLCCL AG0624210437,054203,830SH DFND 00203,830
ATRICURE INCCOM04963C20913,474337,689SH DFND 00337,689
AUTO TRADER GROUP PLC ORD GBP001 ISIN GB00BVYVFW23 SEDOL BVYVCOMG067081041,515208,213SH DFND 00208,213
AUTODESK INCCOM052769106125,734544,281SH DFND 00544,281
AVIDITY BIOSCIENCES INCCOM05370A1082779,828SH DFND 009,828
AXIS BANK GDR EACH REPR 1 INR10 REG S ISIN US05462W1099 SEDOLCOM05462W1091,92165,353SH DFND 0065,353
AXOGEN INCCOM05463X10628724,713SH DFND 0024,713
AZEK CO INCCL A05478C10520,081576,869SH DFND 00576,869
AZUL S ASPONSR ADR PFD05501U10616,4581,250,594SH DFND 001,250,594
BAMBUSER AB NPV ISIN SE0009663834 SEDOL BD8Z3Y2COMW1R91S1028,9338,092,012SH DFND 008,092,012
BARCLAYS BANK PLCIPTH SR B S&P06746P6217,333294,512SH DFND 00294,512
BASICFIT NV 144A REG S ISIN NL0011872650 SEDOL BD9Y9B7COMN1005810011457SH DFND 00457
BEAM THERAPEUTICS INCCOM07373V1052,616106,263SH DFND 00106,263
BERKLEY W R CORPCOM0844231024,89480,034SH DFND 0080,034
BERKSHIRE HATHAWAY INC DELCL B NEW0846707027233,394SH DFND 003,394
BEYOND MEAT INCCOM08862E109114,726690,870SH DFND 00690,870
BIOCRYST PHARMACEUTICALS INCCOM09058V1032,034592,200SH DFND 00592,200
BIOHAVEN PHARMACTL HLDG CO LCOMG111961056,616101,771SH DFND 00101,771
BLACKROCK GOLD CORP COM NPV ISIN CA09258M1014 SEDOL BDCQFK1COM09258M1012,4833,727,108SH DFND 003,727,108
BLUEBIRD BIO INCCOM09609G10023,826441,638SH DFND 00441,638
BOSTON SCIENTIFIC CORPCOM10113710781221,260SH DFND 0021,260
BRP GROUP INCCOM CL A05589G10210,734430,912SH DFND 00430,912
BURNING ROCK BIOTECH LTDSPONSORED ADS12233L107331,300SH DFND 001,300
CALIX INCCOM13100M50956,1213,156,403SH DFND 003,156,403
CALVERT US LRG CAP CORE RESPNSBL INDX CCOM13158276920729SH DFND 00729
CARL ZEISS MEDITEC AG NPV ISIN DE0005313704 SEDOL 5922961COMD148951021,51811,983SH DFND 0011,983
CARVANA COCL A146869102324,2291,453,550SH DFND 001,453,550
CATAPULT GROUP INTERNATIONAL ISIN AU000000CAT9 SEDOL BTL0Y76COMQ2159P101280186,684SH DFND 00186,684
CELLNEX TELECOM SAU EUR025 144A REG S ISIN ES0105066007 SEDOLCOME2R41M10412,241200,749SH DFND 00200,749
CELSIUS HLDGS INCCOM NEW15118V20711,918524,802SH DFND 00524,802
CHARLES RIV LABS INTL INCCOM1598641075,67825,073SH DFND 0025,073
CHART INDS INCCOM PAR $0.0116115Q30843607SH DFND 00607
CHEGG INCCOM163092109117,1231,639,464SH DFND 001,639,464
CHEWY INCCL A16679L10920,379371,669SH DFND 00371,669
CHIPOTLE MEXICAN GRILL INCCOM16965610511SH DFND 001
CHUBB LIMITEDCOMH1467J10412,597108,480SH DFND 00108,480
CITIGROUP INCCOM NEW172967424235SH DFND 0035
CLEARFIELD INCCOM18482P10369134,260SH DFND 0034,260
CLOUDFLARE INCCL A COM18915M107215,2265,241,741SH DFND 005,241,741
CODEXIS INCCOM19200510629,6222,523,168SH DFND 002,523,168
CONTROLADORA VUELA COMP DE ASPON ADR RP 1021240E10521,3952,967,413SH DFND 002,967,413
CORECIVIC INCCOM21871N101658,079SH DFND 008,079
COUPA SOFTWARE INCCOM22266L106103,787378,453SH DFND 00378,453
COVETRUS INCCOM22304C10008SH DFND 008
CREE INCCOM22544710196615,158SH DFND 0015,158
CRIMSON WINE GROUP COM USD001COM22662X1008917,996SH DFND 0017,996
CROWDSTRIKE HLDGS INCCL A22788C10571,973524,125SH DFND 00524,125
D R HORTON INCCOM23331A1094,50259,530SH DFND 0059,530
DATADOG INCCL A COM23804L10323,890233,844SH DFND 00233,844
DELTA AIR LINES INC DELCOM NEW2473617022779,050SH DFND 009,050
DENALI THERAPEUTICS INCCOM24823R105118,8173,316,130SH DFND 003,316,130
DEXCOM INCCOM252131107186,227451,756SH DFND 00451,756
DISH NETWORK CORPORATIONCL A25470M10952,8091,819,135SH DFND 001,819,135
DISNEY WALT COCOM DISNEY2546871064,36335,162SH DFND 0035,162
DIVERSIFIED GAS OIL PLC ORD GBP001 ISIN GB00BYX7JT74 SEDOL BCOMG2891G1059,9157,304,538SH DFND 007,304,538
DOCUSIGN INCCOM256163106315,9691,467,985SH DFND 001,467,985
DOWNEY FINL CORPCOM2610181050200SH DFND 00200
DRAFTKINGS INCCOM CL A26142R1041,90932,441SH DFND 0032,441
EHEALTH INCCOM28238P10912,075152,845SH DFND 00152,845
EIDOS THERAPEUTICS INCCOM28249H10416,945335,349SH DFND 00335,349
ELASTIC N VORD SHSN145061044,61742,797SH DFND 0042,797
EMERGENT BIOSOLUTIONS INCCOM29089Q1054,19240,568SH DFND 0040,568
ENPHASE ENERGY INCCOM29355A107190,4742,306,256SH DFND 002,306,256
ENTERCOM COMMUNICATIONS CORPCL A2936391004226,326SH DFND 0026,326
EPAM SYS INCCOM29414B104117,273362,760SH DFND 00362,760
EQUATOR EXPLORATION COM STK NPVCOMG3084F1280215,000SH DFND 00215,000
EROS STX GLOBAL CORPORATIONSHS NEWG3788M1144419,905SH DFND 0019,905
ESPERION THERAPEUTICS INC NECOM29664W105421,128SH DFND 001,128
ETSY INCCOM29786A10641,562341,706SH DFND 00341,706
EVEREST RE GROUP LTDCOMG3223R1083,49817,709SH DFND 0017,709
EXACT SCIENCES CORPCOM30063P105138,9421,362,848SH DFND 001,362,848
FACEBOOK INCCL A30303M10280,815308,572SH DFND 00308,572
FASTLY INCCL A31188V10039,527421,933SH DFND 00421,933
FATHOM HOLDINGS INCCOM31189V1097,482475,350SH DFND 00475,350
FERGUSON PLC ORD GBP010 ISIN JE00BJVNSS43 SEDOL BJVNSS4COMG3421J10610,945108,375SH DFND 00108,375
FLEX LNG LTD BM USD010 ISIN BMG359472021 SEDOL BJJMGB2COMZZCKKNHC238167,402SH DFND 0067,402
FLOOR & DECOR HLDGS INCCL A339750101130,9961,751,286SH DFND 001,751,286
FOUR SEAS MERCANTILE HLDGS HKD010 ISIN KYG365451049 SEDOL 634COMG3654510494270,000SH DFND 00270,000
FRANCO NEV CORPCOM35185810510,19573,038SH DFND 0073,038
FRANKLIN INCOME CLASS CCOM353496805157,137SH DFND 007,137
FRESHPET INCCOM358039105230,8002,067,171SH DFND 002,067,171
FRIENDLY ENERGY EXPLORATION COM NPVCOM35846A2000690SH DFND 00690
GALAPAGOS NV NPV ISIN BE0003818359 SEDOL B07Q2V5COMB4417010639,287276,423SH DFND 00276,423
GEOPARK LTDUSD SHSG383271052,763375,453SH DFND 00375,453
GLAUKOS CORPCOM37732210243,675881,972SH DFND 00881,972
GLOBAL BLOOD THERAPEUTICS INCOM37890U1083887,028SH DFND 007,028
GLOBANT S ACOML44385109107,287598,636SH DFND 00598,636
GOLDEN MINERALS COCOM3811191062047,017SH DFND 0047,017
GOLDMAN SACHS GROUP INCCOM38141G10470,198349,297SH DFND 00349,297
GOODRX HLDGS INCCOM CL A38246G1082785,000SH DFND 005,000
GROCERY OUTLET HLDG CORPCOM39874R1013,933100,014SH DFND 00100,014
GTT COMMUNICATIONS INCCOM3623931004,743919,090SH DFND 00919,090
GUARDANT HEALTH INCCOM40131M1099768,727SH DFND 008,727
H & E EQUIPMENT SERVICES INCCOM4040301082,609132,709SH DFND 00132,709
HDFC BANK LTDSPONSORED ADS40415F1017,145143,009SH DFND 00143,009
HEALTHEQUITY INCCOM42226A1071,15322,448SH DFND 0022,448
HEARUSA INC NEWCOM4223603050375SH DFND 00375
HEICO CORP NEWCL A4228062084,55451,364SH DFND 0051,364
HEICO CORP NEWCOM4228061092,11620,219SH DFND 0020,219
HELLOFRESH SE ISIN DE000A161408 SEDOL BYWH8S0COMD3R2MA10036,100647,014SH DFND 00647,014
HUBSPOT INCCOM443573100178,480610,753SH DFND 00610,753
ICICI BANK LIMITEDADR45104G1042,835288,450SH DFND 00288,450
IDEXX LABS INCCOM45168D1043,8059,678SH DFND 009,678
ILLUMINA INCCOM4523271092,4347,875SH DFND 007,875
IMPINJ INCCOM45320410912,653480,192SH DFND 00480,192
INARI MED INCCOM45332Y1099,918143,699SH DFND 00143,699
INFINERA CORPCOM45667G10355,7899,056,677SH DFND 009,056,677
INPHI CORPCOM45772F10720,751184,863SH DFND 00184,863
INSPIRE MED SYS INCCOM457730109128,916998,964SH DFND 00998,964
INSULET CORPCOM45784P1015,13421,701SH DFND 0021,701
INTERBREW PLC GDREACH REPR 1 A SH REG SCOM45845T3080200SH DFND 00200
INTL GNRL INSURANCE HLDNGS LSHSG4809J10613,6421,907,912SH DFND 001,907,912
INTUITIVE SURGICAL INCCOM NEW46120E602122,271172,324SH DFND 00172,324
INVITAE CORPCOM46185L103307,4127,091,386SH DFND 007,091,386
IRHYTHM TECHNOLOGIES INCCOM45005610694,472396,756SH DFND 00396,756
IWG PLC ORD GBP001 ISIN JE00BYVQYS01 SEDOL BYVQYS0COMG4969N10354,06216,083,661SH DFND 0016,083,661
JAMF HLDG CORPCOM47074L10511,133296,022SH DFND 00296,022
JPMORGAN CHASE & COCOM46625H1001,56516,253SH DFND 0016,253
JUST EAT TAKEAWAYCOM NV EUR004 144A REG S ISIN NL0012015705COMZZDLN2RN72241,990SH DFND 001,990
KAMBI GROUP PLC EUR0003 ISIN MT0000780107 SEDOL BMNQDC1COMX4170A107371,118SH DFND 001,118
KB HOMECOM48666K1093138,147SH DFND 008,147
KIRKLAND LAKE GOLD LTDCALL49741E90016,304334,573SH DFND 00334,573
KORNIT DIGITAL LTDSHSM6372Q11391,9801,417,919SH DFND 001,417,919
KRYSTAL BIOTECH INCCOM5011471023087,146SH DFND 007,146
KURA SUSHI USA INCCL A COM501270102392,973SH DFND 002,973
LEGEND BIOTECH CORPSPONSORED ADS52490G10251816,768SH DFND 0016,768
LEMONADE INCCOM52567D1075,056101,683SH DFND 00101,683
LGI HOMES INCCOM50187T106125,7751,082,678SH DFND 001,082,678
LI NING CO LTD HKD01 ISIN KYG5496K1242 SEDOL B01JCK9COMG5496K124214,621SH DFND 004,621
LIBERTY MEDIA CORP DELCOM A BRAVES GRP5312297062,660127,390SH DFND 00127,390
LIBERTY MEDIA CORP DELCOM C BRAVES GRP5312298884,721224,707SH DFND 00224,707
LIBERTY MEDIA CORP DELCOM SER C FRMLA5312298542,29663,296SH DFND 0063,296
LIVE NATION ENTERTAINMENT INCOM53803410915278SH DFND 00278
LIVEPERSON INCCOM538146101521,000SH DFND 001,000
LIVONGO HEALTH INCCOM539183103203,6951,454,443SH DFND 001,454,443
LOVESAC COMPANYCOM54738L10978828,423SH DFND 0028,423
LULULEMON ATHLETICA INCCOM55002110937,406113,567SH DFND 00113,567
LUMENTUM HLDGS INCCOM55024U10975910,096SH DFND 0010,096
LYFT INCCL A COM55087P1041,20643,770SH DFND 0043,770
MAG SILVER CORPCOM55903Q10425,7831,585,661SH DFND 001,585,661
MAGENTA THERAPEUTICS INCCOM55910K10829,0044,265,282SH DFND 004,265,282
MAGNOLIA OIL & GAS CORPCL A5596631092,281441,202SH DFND 00441,202
MAINSTAY EPOCH GL EQUITY YIELD CL CCOM56063J8729540SH DFND 00540
MARTIN MARIETTA MATLS INCCOM57328410625,734109,338SH DFND 00109,338
MASTERCARD INCORPORATEDCL A57636Q10426,93679,652SH DFND 0079,652
MATCH GROUP INC NEWCOM57667L10799,351897,888SH DFND 00897,888
MAXAR TECHNOLOGIES INCCOM57778K10532,1011,287,116SH DFND 001,287,116
MAYVILLE ENGINEERING CO INCCOM57860510751355,860SH DFND 0055,860
MERCADOLIBRE INCCOM58733R102157,793145,770SH DFND 00145,770
MGP INGREDIENTS INC NEWCOM55303J10683521,012SH DFND 0021,012
MICROSOFT CORPCOM59491810460,964289,848SH DFND 00289,848
MOLECULAR TEMPLATES INCCOM6085501095,615514,159SH DFND 00514,159
MONGODB INCCL A60937P106173,393748,965SH DFND 00748,965
MONOLITHIC PWR SYS INCCOM60983910512,44944,521SH DFND 0044,521
MYOKARDIA INCCOM62857M1051,69012,395SH DFND 0012,395
MYOVANT SCIENCES LTDCOMG637AM1022,587184,128SH DFND 00184,128
NATERA INCCOM63230710496,5691,336,778SH DFND 001,336,778
NATIONAL VISION HLDGS INCCOM63845R10723603SH DFND 00603
NETCOMPANY GROUP AS DKK1 144A ISIN DK0060952919 SEDOL BFYDWS1COMK7020C10277,606935,654SH DFND 00935,654
NETFLIX INCCOM64110L106543,0881,086,110SH DFND 001,086,110
NEW PACIFIC METALS CORP COM NPV ISIN CA6478241012 SEDOL BF4CP8COM64782410110,2262,120,979SH DFND 002,120,979
NEW YORK TIMES COCL A650111107120,4942,815,928SH DFND 002,815,928
NIKE INCCL B65410610317,361138,289SH DFND 00138,289
NINTENDO 8 ADR REP ORDCOM6544453033334,713SH DFND 004,713
NIU TECHNOLOGIESADS65481N10020610,707SH DFND 0010,707
NOBLE MIDSTREAM PARTNERS LPCOM UNIT REPST65506L1057910SH DFND 00910
NORDSTROM INCCOM6556641001,18499,298SH DFND 0099,298
NORTHERN DATA AG ORD SHS ISIN DE000A0SMU87 SEDOL BWT5WX6COMD5S1LG1122103,371SH DFND 003,371
NV5 GLOBAL INCCOM62945V10934644SH DFND 00644
NVIDIA CORPORATIONCOM67066G104116,444215,152SH DFND 00215,152
NYXOAH SA NPV ISIN BE0974358906 SEDOL BN782G7COMB6S7WD1062,443106,274SH DFND 00106,274
OAK STR HEALTH INCCOM67181A107106,5091,993,055SH DFND 001,993,055
OCADO GROUP PLC ORD GBP002 ISIN GB00B3MBS747 SEDOL B3MBS74COMG6718L106374,26910,550,378SH DFND 0010,550,378
OKTA INCCL A679295105322,7361,509,169SH DFND 001,509,169
ONEWATER MARINE INCCL A COM68280L10118,985926,552SH DFND 00926,552
OPTION CARE HEALTH INCCOM NEW68404L20131,3732,346,538SH DFND 002,346,538
OUTSET MED INCCOM6901451074,90198,017SH DFND 0098,017
PAGERDUTY INCCOM69553P1003,891143,515SH DFND 00143,515
PALANTIR TECHNOLOGIES INCCL A69608A10818018,987SH DFND 0018,987
PALOMAR HLDGS INCCOM69753M10515,021144,098SH DFND 00144,098
PARAMOUNT RESOURCES LIMITED COM NPV CLASS A ISIN CA6993202069 SCOM69932020614995,783SH DFND 0095,783
PAYPAL HLDGS INCCOM70450Y10339,498200,469SH DFND 00200,469
PDF SOLUTIONS INCCOM69328210552027,772SH DFND 0027,772
PELOTON INTERACTIVE INCCL A COM70614W100358,9073,616,555SH DFND 003,616,555
PENN NATL GAMING INCCOM70756910946,866644,643SH DFND 00644,643
PENN TREATY AMERN CORP COM NEWCOM7078744000125SH DFND 00125
PENSKE AUTOMOTIVE GRP INCCOM70959W1032,85359,871SH DFND 0059,871
PENUMBRA INCCOM70975L1074152,133SH DFND 002,133
PINDUODUO INCSPONSORED ADS72230410218,585250,637SH DFND 00250,637
PINTEREST INCCL A72352L10691822,121SH DFND 0022,121
POOL CORPCOM73278L105110,247329,547SH DFND 00329,547
PREVAIL THERAPEUTICS INCCOM74140Y10105SH DFND 005
PROFOUND MED CORPCOM NEW74319B5022,363133,931SH DFND 00133,931
PROOFPOINT INCCOM7434241034,79645,441SH DFND 0045,441
PROVENTION BIO INCCOM74374N10227,6022,151,402SH DFND 002,151,402
PURPLE INNOVATION INCCOM74640Y10626,1281,051,013SH DFND 001,051,013
Q2 HLDGS INCCOM74736L10957,963635,144SH DFND 00635,144
QUANTERIX CORPCOM74766Q10199,5192,949,599SH DFND 002,949,599
QUIDEL CORPCOM74838J1018,30537,855SH DFND 0037,855
QUOTIENT LTDSHSG73268107570110,808SH DFND 00110,808
REDFIN CORPCOM75737F10833,652673,977SH DFND 00673,977
REECE LIMITED NPV ISIN AU000000REH4 SEDOL 6728801COMQ805281382,949317,675SH DFND 00317,675
REGENERON PHARMACEUTICALSCOM75886F1073,7346,671SH DFND 006,671
RELAY THERAPEUTICS INCCOM75943R10286,2662,025,501SH DFND 002,025,501
RENAISSANCERE HLDGS LTDCOMG7496G1033,34819,724SH DFND 0019,724
RENALYTIX AI PLCADS75973T10130,4692,499,532SH DFND 002,499,532
RENALYTIX AI PLC ORD GBP00025 ISIN GB00BYWL4Y04 SEDOL BYWL4Y0COMG7489R1081,257228,792SH DFND 00228,792
REPARE THERAPEUTICS INCCOM7602731021003,239SH DFND 003,239
REPLIGEN CORPCOM75991610971,255482,953SH DFND 00482,953
REYNA SILVER CORP COM NPV ISIN CA76170Q1063 SEDOL BMG11D0COM76170Q1061,5972,344,727SH DFND 002,344,727
RIGHTMOVE ORD GBP0001 ISIN GB00BGDT3G23 SEDOL BGDT3G2COMG7565D1066,909852,608SH DFND 00852,608
RINGCENTRAL INCCL A76680R206264,245962,254SH DFND 00962,254
ROKU INCCOM CL A77543R102419,0732,219,664SH DFND 002,219,664
ROYALTY PHARMA PLCSHS CL AG7709Q1042,52560,015SH DFND 0060,015
SAFARICOM PLC KES005 ISIN KE1000001402 SEDOL B2QN3J6COMV7458710225,68793,840,157SH DFND 0093,840,157
SAFETY INS GROUP INCCOM78648T1003214,645SH DFND 004,645
SALESFORCE COM INCCOM79466L30244,941178,819SH DFND 00178,819
SAREPTA THERAPEUTICS INCCOM803607100121,366864,248SH DFND 00864,248
SCHRODINGER INCCOM80810D10319,530411,064SH DFND 00411,064
SCIENTIFIC GAMES CORPCOM80874P10938110,904SH DFND 0010,904
SCOTTS MIRACLE GRO COCL A81018610655,267361,432SH DFND 00361,432
SELECTQUOTE INCCOM816307300814,003SH DFND 004,003
SEMLER SCIENTIFIC INC COM USD0001COM81684M1042,94155,094SH DFND 0055,094
SENESTECH INCCOM NEW81720R2086936,900SH DFND 0036,900
SENSEONICS HLDGS INCCOM81727U1055,63814,558,073SH DFND 0014,558,073
SERES THERAPEUTICS INCCOM81750R10290,1793,185,420SH DFND 003,185,420
SERVICENOW INCCOM81762P10253,776110,878SH DFND 00110,878
SHAKE SHACK INCCL A819047101192,8232,990,433SH DFND 002,990,433
SHERWIN WILLIAMS COCOM8243481061,0991,577SH DFND 001,577
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SHOPIFY INCCL A82509L107432,181422,477SH DFND 00422,477
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SI BONE INCCOM82570410947,0901,985,250SH DFND 001,985,250
SILK RD MED INCCOM82710M1007,912117,728SH DFND 00117,728
SILVERCREST METALS INCCOM82836310172,0678,488,411SH DFND 008,488,411
SINTX TECHNOLOGIES INCCOM NEW829392307071SH DFND 0071
SITEONE LANDSCAPE SUPPLY INCCOM82982L10331,095254,983SH DFND 00254,983
SITIME CORPCOM82982T10617,323206,150SH DFND 00206,150
SKEENA RESOURCES COM NPVPOST REV SPLT ISIN CA83056P8064 SEDOLCOM83056P8068,1303,977,774SH DFND 003,977,774
SLACK TECHNOLOGIES INCCOM CL A83088V10235213,122SH DFND 0013,122
SMARTSHEET INCCOM CL A83200N10355011,126SH DFND 0011,126
SNAP INCCL A83304A10662,8092,405,551SH DFND 002,405,551
SNOWFLAKE INCCL A83344510935,301140,643SH DFND 00140,643
SOCIAL CAP HDOSPHIA HLDG COSHS CL AG8250T10914,575767,494SH DFND 00767,494
SONOS INCCOM83570H10879352,247SH DFND 0052,247
SPDR GOLD TRGOLD SHS78463V10714,94584,379SH DFND 0084,379
SPLUNK INCCOM84863710416,11585,658SH DFND 0085,658
SPORTSMANS WHSE HLDGS INCCOM84920Y1064,272298,537SH DFND 00298,537
SPOTIFY TECHNOLOGY S ASHSL8681T102165,296681,435SH DFND 00681,435
SPROUT SOCIAL INCCOM CL A85209W10912,875334,404SH DFND 00334,404
SQUARE INCCL A852234103162,223997,987SH DFND 00997,987
SS&C TECHNOLOGIES HLDGS INCCOM78467J10036,283599,527SH DFND 00599,527
STAAR SURGICAL COCOM PAR $0.0185231230512212SH DFND 00212
STAMPS COM INCCOM NEW8528572004661,932SH DFND 001,932
STAR BULK CARRIERS CORP.SHS PARY8162K2046910,000SH DFND 0010,000
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SUNRUN INCCOM86771W105111,1751,442,517SH DFND 001,442,517
SUNTIMES MEDIA GROUP INC CLASS A COM USD001 NO STOCKHOLDER EQUCOM86688Q1000650SH DFND 00650
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SVMK INCCOM78489X1033,147142,345SH DFND 00142,345
TACTILE SYS TECHNOLOGY INCCOM87357P1001504,103SH DFND 004,103
TAL EDUCATION GROUPSPONSORED ADS874080104120,8611,589,441SH DFND 001,589,441
TALON THERAPEUTICS CVR NEWCOM874CNT1080125SH DFND 00125
TANDEM DIABETES CARE INCCOM NEW875372203158,9411,400,361SH DFND 001,400,361
TAYSHA GENE THERAPIES INCCOM SHS87761910697243,410SH DFND 0043,410
TELADOC HEALTH INCCOM87918A105186,863852,323SH DFND 00852,323
TENCENT HOLDINGS LIMITED HKD000002 ISIN KYG875721634 SEDOL BMCOMG8757216388,1051,334,929SH DFND 001,334,929
TESLA INCCOM88160R101987,7272,302,340SH DFND 002,302,340
THE A2 MILK COMPANY LTD NPV ISIN NZATME0002S8 SEDOL BWSRTS7COMZZCXTSUT21,972195,831SH DFND 00195,831
THOR INDS INCCOM8851601015,06453,163SH DFND 0053,163
T-MOBILE US INCCOM87259010477,239675,398SH DFND 00675,398
TRANSDIGM GROUP INCCOM8936411007,99316,824SH DFND 0016,824
TREAN INS GROUP INCCOM89457R1012,562168,004SH DFND 00168,004
TRINE ACQUISITION CORPCOM CL A89628U10813612,627SH DFND 0012,627
TRUPANION INCCOM89820210647,199598,210SH DFND 00598,210
TWILIO INCCL A90138F10224,34098,508SH DFND 0098,508
TWIST BIOSCIENCE CORPCOM90184D10097312,808SH DFND 0012,808
TWITTER INCCOM90184L1023,61681,251SH DFND 0081,251
UBER TECHNOLOGIES INCCOM90353T10046,4011,271,953SH DFND 001,271,953
UNITY SOFTWARE INCCOM91332U10181,479933,532SH DFND 00933,532
VANECK VECTORS ETF TRGOLD MINERS ETF92189F10630,142769,719SH DFND 00769,719
VEEVA SYS INCCL A COM92247510817,33261,637SH DFND 0061,637
VERACYTE INCCOM92337F10799,9943,077,700SH DFND 003,077,700
VERIZON COMMUNICATIONS INCCOM92343V10413,575228,195SH DFND 00228,195
VICOR CORPCOM9258151025,28968,039SH DFND 0068,039
VIR BIOTECHNOLOGY INCCOM92764N1021,85554,034SH DFND 0054,034
VIRGIN GALACTIC HOLDINGS INCCOM92766K10655328,734SH DFND 0028,734
VISA INCCOM CL A92826C8394102,049SH DFND 002,049
VITAL FARMS INCCOM92847W1039,992246,531SH DFND 00246,531
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WATSCO INCCOM94262220087,812377,055SH DFND 00377,055
WHEATON PRECIOUS METALS CORPCOM9628791023,83978,243SH DFND 0078,243
WHITING PETE CORP NEWCOM NEW96638750811,731678,483SH DFND 00678,483
WILLOW BIOSCIENCES INC COM NPV POST REV SPLIT ISIN CA97111B40COM97111B404264476,920SH DFND 00476,920
WILLSCOT MOBIL MINI HLDNG COCOM CL A9713781047,427445,250SH DFND 00445,250
WORKDAY INCCL A98138H10119,63091,247SH DFND 0091,247
WUXI BIOLOGICS CAYMAN INC USD0000025 144A REG S ISIN KYG9700COMG9700810974,7833,073,012SH DFND 003,073,012
WYNN RESORTS LTDCOM9831341071101,533SH DFND 001,533
XP INCCL AG9823910927,427657,882SH DFND 00657,882
XYLEM INCCOM98419M10030,479362,331SH DFND 00362,331
ZAI LAB LTDADR98887Q10492,4011,110,984SH DFND 001,110,984
ZILLOW GROUP INCCL A98954M1014234,163SH DFND 004,163
ZILLOW GROUP INCCL C CAP STK98954M20087,377860,097SH DFND 00860,097
ZOOM VIDEO COMMUNICATIONS INCL A98980L101505,7071,075,721SH DFND 001,075,721
ZOOMINFO TECHNOLOGIES INCCOM CL A98980F10411,557268,833SH DFND 00268,833