<?xml version="1.0"?>
<ownershipDocument>

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    <documentType>4</documentType>

    <periodOfReport>2008-04-23</periodOfReport>

    <issuer>
        <issuerCik>0000778164</issuerCik>
        <issuerName>Pacific Ethanol, Inc.</issuerName>
        <issuerTradingSymbol>PEIX</issuerTradingSymbol>
    </issuer>

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            <rptOwnerName>CASCADE INVESTMENT LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>2365 CARILLON POINT</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>KIRKLAND</rptOwnerCity>
            <rptOwnerState>WA</rptOwnerState>
            <rptOwnerZipCode>98033</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
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    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
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            <rptOwnerName>GATES WILLIAM H III</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>ONE MICROSOFT WAY</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>REDMOND</rptOwnerCity>
            <rptOwnerState>WA</rptOwnerState>
            <rptOwnerZipCode>98052</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
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    </reportingOwner>

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    <footnotes></footnotes>

    <remarks>* Duly authorized under Special Power of Attorney appointing Michael Larson attorney-in-fact, dated February 3, 2006, by and on behalf of William H. Gates III, filed as Exhibit 99.1 to Cascade Investment, L.L.C.'s Amendment No. 2 to Schedule 13G with respect to Arch Capital Group Ltd. on March 7, 2006, SEC File No. 005-45257, and incorporated by reference herein.</remarks>

    <ownerSignature>
        <signatureName>Cascade Investment, L.L.C. By: /s/ Michael Larson, Business Manager</signatureName>
        <signatureDate>2008-04-25</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>William H. Gates III By: /s/ Michael Larson*, Attorney-In-Fact</signatureName>
        <signatureDate>2008-04-25</signatureDate>
    </ownerSignature>
</ownershipDocument>
