X0609 4 2026-10-06 0 0000901832 ASTRAZENECA PLC AZN 0002122411 Sharma Mani true 1 FRANCIS CRICK AVENUE CAMBRIDGE BIOMEDICAL CAMPUS CAMBRIDGE X0 CB2 0AA 0 1 0 0 See remarks 0 Ordinary Shares 2026-10-06 4 A 0 2 159.8 A 19290.6989 D Represents the acquisition of shares pursuant to the Issuer's Share Incentive Plan at a price of GBP120.75, which has been converted from British pounds sterling to United States dollars at a conversion rate of GBP1.0000 to $1.3234 on October 2, 2026 as published by the Board of Governors of the Federal Reserve System. SVP, Group Controller and Head of Global Finance Services /s/ Mani Sharma 2026-10-08