<?xml version="1.0"?>
<notificationOfRemoval>

    <schemaVersion>X0203</schemaVersion>

    <exchange>
        <cik>0000876661</cik>
        <entityName>NEW YORK STOCK EXCHANGE LLC</entityName>
    </exchange>

    <issuer>
        <cik>0000901832</cik>
        <entityName>ASTRAZENECA PLC</entityName>
        <fileNumber>001-11960</fileNumber>
        <address>
            <street1>Academy House 136 Hills Rd</street1>
            <city>Cambridge</city>
            <stateOrCountryCode></stateOrCountryCode>
            <stateOrCountry></stateOrCountry>
            <zipCode>CB2 8PA</zipCode>
        </address>
        <telephoneNumber>+44 20 3749 5000</telephoneNumber>
    </issuer>

    <descriptionClassSecurity>1.95% Notes due 2019</descriptionClassSecurity>

    <ruleProvision>17 CFR 240.12d2-2(a)(2)</ruleProvision>

    <signatureData>
        <signatureName>Kristen Braley</signatureName>
        <signatureTitle>Analyst, Regulation</signatureTitle>
        <signatureDate>2019-09-18</signatureDate>
    </signatureData>
</notificationOfRemoval>
