X0304 4/A 2012-03-10 2012-03-13 0000901219 HUMAN GENOME SCIENCES INC HGSI 0001346164 Simpson Curran 14200 SHADY GROVE ROAD ROCKVILLE MD 20850 1 Sr. VP, Operations Common Stock 2012-03-10 4 F 0 1465.0000 8.2300 D 44325.0000 D Restricted stock withheld by Issuer to satisfy tax withholding obligation on the annual vesting of 16,667 restricted stock units ("RSUs"), originally granted on March 10, 2010. 25% of the RSUs vest annually on March 10th each year after. Shares withheld were determined on March 10th, 2012 based on the prior business day's closing price. This amendment is created to correctly state the number of shares sold to satisfy the tax obligation. /s/ Curran M. Simpson 2012-03-19