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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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 M9ntkd8cXzFnAAvI81WwmQ==

<SEC-DOCUMENT>0001225208-11-001464.txt : 20110107
<SEC-HEADER>0001225208-11-001464.hdr.sgml : 20110107
<ACCEPTANCE-DATETIME>20110107115019
ACCESSION NUMBER:		0001225208-11-001464
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20110105
FILED AS OF DATE:		20110107
DATE AS OF CHANGE:		20110107

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Watkins Thomas
		CENTRAL INDEX KEY:			0001307935

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-14169
		FILM NUMBER:		11516323

	MAIL ADDRESS:	
		STREET 1:		785 EAST WESTMINSTER
		CITY:			LAKE FOREST
		STATE:			IL
		ZIP:			60045

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			HUMAN GENOME SCIENCES INC
		CENTRAL INDEX KEY:			0000901219
		STANDARD INDUSTRIAL CLASSIFICATION:	IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES [2835]
		IRS NUMBER:				223178468
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		14200 SHADY GROVE ROAD
		CITY:			ROCKVILLE
		STATE:			MD
		ZIP:			20850-3338
		BUSINESS PHONE:		3013098504

	MAIL ADDRESS:	
		STREET 1:		14200 SHADY GROVE ROAD
		CITY:			ROCKVILLE
		STATE:			MD
		ZIP:			20850
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>doc4.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0303</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2011-01-05</periodOfReport>

    <issuer>
        <issuerCik>0000901219</issuerCik>
        <issuerName>HUMAN GENOME SCIENCES INC</issuerName>
        <issuerTradingSymbol>HGSI</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001307935</rptOwnerCik>
            <rptOwnerName>Watkins Thomas</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>14200 SHADY GROVE ROAD</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>ROCKVILLE</rptOwnerCity>
            <rptOwnerState>MD</rptOwnerState>
            <rptOwnerZipCode>20850</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>1</isOfficer>
            <officerTitle>Chief Executive Officer</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2011-01-05</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>60000.0000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>24.1600</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>66000.0000</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>By Children</value>
                    <footnoteId id="F1"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>166075.1200</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes>
        <footnote id="F1">Shares acquired by Mr. Watkins' children as a gift from Mr. Watkins' father, who does not share his household.  20,000 shares by Caroline S. Watkins, 20,000 shares by Catherine R. Watkins and 20,000 shares by Hays T. Watkins IV.  Mr. Watkins disclaims any beneficial ownership of these shares, and this report shall not be deemed an admission that the reporting person is the beneficial owner of the shares for purposes of Section 16 or for any other purpose.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ H. Thomas  Watkins</signatureName>
        <signatureDate>2011-01-07</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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