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PROSPECTUS SUPPLEMENT No. 11                    Filed Pursuant to Rule 424(b)(3)
(to Prospectus dated May 16, 2000)              Registration No. 333-36384



                           HUMAN GENOME SCIENCES, INC.

                              --------------------

                                  $300,000,000
                 3 3/4% Convertible Subordinated Notes Due 2007
                                       and
                        1,369,863 Shares of Common Stock
                      Issuable Upon Conversion of the Notes

                              --------------------


               The following information supplements information contained in
        our prospectus dated May 16, 2000, relating to the potential offer and
        sale from time to time by holders of the notes and the underlying shares
        of our common stock. See "Plan of Distribution" in our prospectus.

               This prospectus supplement may only be delivered or used in
        connection with our prospectus. This prospectus supplement is
        incorporated by reference into our prospectus. Our common stock is
        listed on The Nasdaq National Market under the symbol "HGSI."

               NEITHER THE SEC NOR ANY STATE SECURITIES COMMISSION HAS APPROVED
        OR DISAPPROVED OF THESE SECURITIES OR DETERMINED IF THIS PROSPECTUS
        SUPPLEMENT OR THE PROSPECTUS IS TRUTHFUL OR COMPLETE. ANY REPRESENTATION
        TO THE CONTRARY IS A CRIMINAL OFFENSE.







                  Prospectus Supplement dated December 29, 2000


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        The notes were originally issued by us and sold by Credit Suisse First
Boston Corporation, as initial purchaser, in a transaction exempt from the
registration requirements of the Securities Act to persons reasonably believed
by the initial purchaser to be qualified institutional buyers or other
institutional accredited investors. Selling holders, including their
transferees, pledgees or donees or their successors, may from time to time offer
and sell any or all of the notes and common stock into which the notes are
convertible.

                              --------------------

        The following table supplements the information in our prospectus with
respect to the selling holders and the principal amounts of notes and common
stock they beneficially own that may be offered under our prospectus. The
information is based on information provided by or on behalf of the selling
holders. All information provided in this prospectus supplement is as of
December 28, 2000.

        The selling holders may offer all, some or none of the notes or common
stock into which the notes are convertible. Thus, we cannot estimate the amount
of the notes or the common stock that will be held by the selling holders upon
termination of any sales. The column showing ownership after completion of the
offering assumes that the selling holders will sell all of the securities
offered by this prospectus supplement. In addition, the selling holders
identified below may have sold, transferred or otherwise disposed of all or a
portion of their notes since the date on which they provided the information
about their notes in transactions exempt from the registration requirements of
the Securities Act. None of the selling holders has had any material
relationship with us or our affiliates within the past three years. No selling
holder named in the table below beneficially owns one percent or more of our
common stock. Common stock owned prior to the offering and after completion of
the offering includes shares of common stock issuable upon conversion of our
5 1/2% Convertible Subordinated Notes Due 2006 and 5% Convertible Subordinated
Notes Due 2007.



                                                                                             COMMON STOCK
                                                                                              OWNED AFTER
                                      PRINCIPAL AMOUNT OF       COMMON STOCK      COMMON      COMPLETION
                                      NOTES BENEFICIALLY       OWNED PRIOR TO      STOCK         OF THE
NAME                                  OWNED AND OFFERED         THE OFFERING      OFFERED      OFFERING
- ----                                  -------------------      --------------     -------    ------------

                                                                                 
The Class 1C Company LTD. .........       $  500,000                2,283          2,283           --


        Information concerning the selling holders may change from time to time
and any changed information will be set forth in future prospectus supplements
if and when necessary. In addition, the per share conversion price and the
"make-whole" payment, if any, and therefore the number of shares of common stock
issuable upon conversion or redemption of the notes, are subject to adjustment.
See "Description of Securities - Conversion Rights" and "-- Provisional
Redemption" in the prospectus. As a result, the aggregate principal amount of
notes and the number of shares of common stock issuable upon conversion or
redemption may increase or decrease.


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