-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 KVlDb27GP/FGEo/REBSG+qC0pnIdQ1vpYoQYfeBZx9u+n4cOsXR2Y8BlVWDh4d09
 s7fmrwJOw5x4bgF4zNG+Jw==

<SEC-DOCUMENT>0000901219-03-000047.txt : 20031212
<SEC-HEADER>0000901219-03-000047.hdr.sgml : 20031212
<ACCEPTANCE-DATETIME>20031212135923
ACCESSION NUMBER:		0000901219-03-000047
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20031210
FILED AS OF DATE:		20031212

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			MCKAY SUSAN D BATESON
		CENTRAL INDEX KEY:			0001191234

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-14169
		FILM NUMBER:		031051454

	BUSINESS ADDRESS:	
		STREET 1:		9410 KEY WEST AVE
		CITY:			ROCKVILLE
		STATE:			MD
		ZIP:			20850-3338
		BUSINESS PHONE:		3012516039

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			HUMAN GENOME SCIENCES INC
		CENTRAL INDEX KEY:			0000901219
		STANDARD INDUSTRIAL CLASSIFICATION:	IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES [2835]
		IRS NUMBER:				223178468
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		9410 KEY W AVE
		CITY:			ROCKVILLE
		STATE:			MD
		ZIP:			20850-3338
		BUSINESS PHONE:		3013098504

	MAIL ADDRESS:	
		STREET 1:		9410 KEY WEST AVE
		CITY:			ROCKVILLE
		STATE:			MD
		ZIP:			20850
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>bat158.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>
    <schemaVersion>X0201</schemaVersion>

    <documentType>4</documentType>
	<periodOfReport>2003-12-10</periodOfReport>
	<notSubjectToSection16>0</notSubjectToSection16>
    <issuer>
        <issuerCik>0000901219</issuerCik>
        <issuerName>HUMAN GENOME SCIENCES INC</issuerName>
        <issuerTradingSymbol>HGSI</issuerTradingSymbol>
	</issuer>
	<reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001191234</rptOwnerCik>
            <rptOwnerName>MCKAY SUSAN D BATESON</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>14200 SHADY GROVE ROAD</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>ROCKVILLE</rptOwnerCity>
            <rptOwnerState>MD</rptOwnerState>
            <rptOwnerZipCode>20850</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
            <reportingOwnerRelationship>
			<isDirector>0</isDirector>
			<isOfficer>1</isOfficer>
			<isTenPercentOwner>0</isTenPercentOwner>
			<isOther>0</isOther>
			<officerTitle>Senior Vice President</officerTitle>
		</reportingOwnerRelationship>
	</reportingOwner>
	<derivativeTable>
		<derivativeTransaction>
			<securityTitle>
				<value>Employee Stock Option - Right to Buy</value>
			</securityTitle>
			<conversionOrExercisePrice>
				<value>12.38</value>
			</conversionOrExercisePrice>
			<transactionDate>
				<value>2003-12-10</value>
			</transactionDate>
			<deemedExecutionDate>
			</deemedExecutionDate>
			<transactionCoding>
				<transactionFormType>4</transactionFormType>
				<transactionCode>A</transactionCode>
				<equitySwapInvolved>0</equitySwapInvolved>
			</transactionCoding>
			<transactionAmounts>
				<transactionShares>
					<value>85000</value>
				</transactionShares>
				<transactionPricePerShare>
					<value>0</value>
				</transactionPricePerShare>
				<transactionAcquiredDisposedCode>
					<value>A</value>
				</transactionAcquiredDisposedCode>
			</transactionAmounts>
			<exerciseDate>
				<footnoteId id="F1"/>
			</exerciseDate>
			<expirationDate>
				<value>2013-12-10</value>
			</expirationDate>
			<underlyingSecurity>
				<underlyingSecurityTitle>
					<value>Common Stock</value>
				</underlyingSecurityTitle>
				<underlyingSecurityShares>
					<value>85000.00</value>
				</underlyingSecurityShares>
			</underlyingSecurity>
			<postTransactionAmounts>
				<sharesOwnedFollowingTransaction>
					<value>85000.00</value>
				</sharesOwnedFollowingTransaction>
			</postTransactionAmounts>
			<ownershipNature>
				<directOrIndirectOwnership>
					<value>D</value>
				</directOrIndirectOwnership>
				<natureOfOwnership>
					<value/>
				</natureOfOwnership>
			</ownershipNature>
		</derivativeTransaction>
	</derivativeTable>
	<footnotes>
		<footnote id="F1">One-eighth of the shares granted vest on June 10, 2004, the six-month anniversary date of the grant, and the remaining shares  vest monthly on a ratable basis for the next forty-two months beginning July 10, 2004.</footnote>
	</footnotes>
	<remarks>
	</remarks>
	<ownerSignature>
		<signatureName>By: Steven C. Mayer, Pursuant to Power of Attorney</signatureName>
		<signatureDate>2003-12-12</signatureDate>
	</ownerSignature>
</ownershipDocument>

</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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