SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, DC 20549

FORM 8-K

CURRENT REPORT
PURSUANT TO SECTION 13 OR 13(D) OF THE
SECURITIES EXCHANGE ACT OF 1934

APRIL 28, 2004

Date of Report
(Date of earliest event reported)

HUMAN GENOME SCIENCES, INC.

(Exact Name of Registrant as Specified in Charter)

Delaware
(State or Other Jurisdiction
of Incorporation) 0-022962
(Commission File Number) 22-3178468
(IRS Employer
Identification Number)

14200 Shady Grove Road, Rockville, Maryland 20850-7464 (Address of principal executive offices and zip code)

Registrant’s telephone number, including area code: (301) 309-8504

Item 12. Disclosure of Results of Operations and Financial Condition

     On April 28, 2004, Human Genome Sciences, Inc. issued a press release announcing its financial results for the three months ended March 31, 2004. A copy of the release is furnished as Exhibit 99.1 to this Current Report on Form 8-K.

     The information in this Form 8-K and the Exhibit attached hereto shall not be deemed “filed” for the purposes of Section 18 of the Securities Exchange Act of 1934, nor shall it be deemed incorporated by reference in any filing under the Securities Act of 1933, except as shall be expressly set forth by specific reference in such filing.

Item 7. Financial Statements and Exhibits

(c) Exhibits

Exhibit Description

99.1 Press Release issued April 28, 2004

SIGNATURES

     Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

HUMAN GENOME SCIENCES, INC.

Date: April 28, 2004 By: /s/ Steven C. Mayer Steven C. Mayer
Executive Vice President and Chief Financial Officer